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Updated: Jan 10, 2026

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水网作为蛋白质中的疏水识别动机

Serena G Piticchio1, Miriam Martínez-Cartró1, Salvatore Scaffidi1

  • 1Departament de Farmacia i Tecnología Farmacèutica, i Fisicoquímica, Institut de Biomedicina (IBUB), Universitat de Barcelona, Av. Joan XXIII, 27-31, E-08028, Barcelona, Spain.

Angewandte Chemie (International ed. in English)
|November 21, 2025
PubMed
概括

水网络,不仅仅是无极群,可以驱动像BRD4这样的蛋白质中的疏水相互作用. 这一发现揭示了对药物发现和蛋白质设计至关重要的新识别元素.

关键词:
水分子的界面界面.药品化学 药品化学 是一个分子识别分子识别蛋白质与配体的相互作用

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