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Updated: Jan 10, 2026

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解码Allostery:互动如何锁定S100B形状以及K55A突变教我们什么

Riya Samanta1,2, Xinhao Zhuang3, Manuel Gondolesi4

  • 1Biophysics Graduate Program, University of Maryland, College Park, Maryland 20742, United States.

Journal of chemical information and modeling
|November 21, 2025
PubMed
概括

在S100B蛋白质中的动态质对生物系统至关重要. 与S100B结合的TRTK通过改变子单元相互作用来增强 (Ca2+) 结合,这一过程通过突变发生和模拟进行了研究.

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Binding sites linkages can regulate a protein's function.  For example, enzyme activity is often regulated through a feedback mechanism where the end product of the biochemical process serves as an inhibitor.
Aspartate transcarbamoylase (ATCase) is a cytosolic enzyme that catalyzes the condensation of L-aspartate and carbamoyl phosphate to  N-carbamoyl-L-aspartate. This reaction is the first step in pyrimidine biosynthesis. UTP and CTP, the end products of the pyrimidine synthesis...
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Allosteric proteins have more than one ligand binding site; the binding of a ligand to any of these sites influences the binding of ligands to the other sites. When a protein is allosteric, its binding sites are called coupled or linked.  In the case of enzymes, the site that binds to the substrate is known as the active site and the other site is known as the regulatory site. When a ligand binds to the regulatory site, this leads to conformational changes in the protein that can influence...
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