认知训练可以改善多发性硬化症患者的工作记忆,处理速度和神经效率
Ryan F O'Donnell1,2, Janet L Shucard1,2, Thomas J Covey1,2
1Division of Cognitive and Behavioral Neurosciences, Department of Neurology, The Jacobs School of Medicine and Biomedical Sciences, SUNY University at Buffalo, Buffalo, NY, USA.
Journal of clinical and experimental neuropsychology
|November 21, 2025
概括
认知训练,特别是工作记忆 (WM) 训练,可以改善多发性硬化症 (MS) 患者的认知功能和神经效率. 此次培训还显示了处理速度 (PS) 和任务传输的好处.
科学领域:
- 神经科学是一个神经科学.
- 认知心理学 认知心理学
- 康复科学 康复科学 康复科学
背景情况:
- 多发性硬化症 (MS) 是一种中枢神经系统脱髓化的疾病.
- 认知障碍,特别是工作记忆 (WM) 和处理速度 (PS),在MS中很普遍.
- 认知培训为缓解这些缺陷提供了一个有希望的途径.
研究的目的:
- 研究WM和处理速度 (PS) 训练对MS患者认知任务的影响.
- 用神经效率的行为指数来评估训练的有效性,例如反应时间变化 (RT变化).
主要方法:
- 43名复发性复发性多发性硬化症参与者被分配到WM培训,视觉搜索 (VS) 培训或没有培训的对照组.
- 参与者接受了前后测试,评估WM和VS任务,测量准确性,反应时间 (RT) 和RT变异性.
- 家庭培训是在大约4-5周内进行的.
主要成果:
- WM培训组在双背WM任务中表现出显著的改进,并证明了对VS任务的转移效应.
- VS训练组在VS任务中取得了改进,并在双背任务中表现出更快的RT.
- 在训练组中,RT变异性下降,表明神经效率提高.
结论:
- WM培训提高神经效率,处理速度,并导致MS患者的交叉任务转移.
- 对于评估训练诱导的神经效率的改善,RT变异性是一个有价值的标志物.
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