人类T细胞白血病病毒1型的下降 孕妇携带者和对水平传播的新兴担忧:日本的一项全国性调查
Manabu Ogoyama1,2, Akihiko Sekizawa1,3, Shunji Suzuki1,4
1Division of Maternal and Child Health, Japan Association of Obstetricians and Gynecologists, Shinjyuku-ku, Tokyo, Japan.
The journal of obstetrics and gynaecology research
|November 21, 2025
概括
在日本孕妇中,人类T细胞白血病病毒1型 (HTLV-1) 的患病率有所下降,在年轻年龄组的患病率较低. 横向传播仍然是一个问题,需要持续的预防工作.
科学领域:
- 病毒学 病毒学
- 公共卫生 公共卫生
- 流行病学 流行病学
背景情况:
- 人类T细胞白血病病毒1型 (HTLV-1) 是一个重要的公共卫生问题.
- 了解孕妇群体中HTLV-1的患病率对于母婴健康至关重要.
- 之前的研究表明,在日本各地的HTLV-1发病率各不相同.
研究的目的:
- 确定目前在日本孕妇中HTLV-1的流行率.
- 根据年龄和地理区域分析HTLV-1的流行情况.
- 评估水平传播对HTLV-1病例的贡献.
主要方法:
- 2025年进行了一项全国性问卷调查,收集了2024年的数据.
- 1935 年交付设施报告了交付和 HTLV-1 载体病例.
- 根据地区和年龄的流行率分析,使用先前的阴性测试结果估计横向传播.
主要成果:
- 1297个设施的响应率为67.0%,覆盖了461,271次交付.
- HTLV-1携带者患病率为0.07%,在九州和冲绳 (0.25%) 的患病率最高.
- 在较年轻的队列 (出生≥1990年) 中,患病率下降,并且16.3%的多胞胎携带者先前有负面测试,表明水平传播.
结论:
- 在日本,孕妇中HTLV-1的患病率有所下降,这归因于有效的母婴传播预防.
- 横向传播是一个重要的因素,特别是在城市地区.
- 持续的围产期查,咨询和加强性传播策略至关重要.
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