暴露于除草剂草甘会导致不适当的威胁反应,并改变肠道微生物的组成
Mauricio Cáceres-Chacón1, Osmarie Martínez-Guzmán1,2, Héctor A Haddock-Martínez1
1Department of Anatomy and Neurobiology, University of Puerto Rico School of Medicine, San Juan, PR, United States.
Frontiers in toxicology
|November 21, 2025
概括
即使在安全剂量的草甘暴露,也会通过改变大脑活动和肠道细菌,增加老鼠的焦虑类行为. 这表明这种常见的除草剂可能会导致焦虑症的潜在风险.
科学领域:
- 神经科学是一个神经科学.
- 毒理学 毒理学 毒理学
- 微生物学 微生物学
背景情况:
- 草甘是一种广泛使用的除草剂,被怀疑会导致焦虑症.
- 机制可能涉及大脑功能或肠道微生物群的改变.
- 之前的研究使用了高剂量;安全剂量的影响是未知的.
研究的目的:
- 研究一种安全剂量的草甘对成年雄性大鼠焦虑相关行为的影响.
- 探索大脑活动和肠道微生物群的潜在变化.
主要方法:
- 大鼠接受了安全剂量的草甘16周.
- 使用开放场地和升高加迷宫测试来评估类似焦虑的行为.
- 评估了社会互动,恐惧条件,大脑活动 (免疫组织化学) 和肠道微生物群 (16S rRNA分析).
主要成果:
- 草甘增加了类似焦虑的行为,并改变了终端细胞的床核中的细胞活动.
- 观察到与新型物体的相互作用减少,以及对新型音调的反应增加结.
- 发生了肠道失生症,乳杆菌物种的数量减少.
结论:
- 暴露于草甘会增加威胁解释和与焦虑相关的大脑活动.
- 它诱导肠道失调,并减少乳酸菌,可能通过血清素途径加剧焦虑.
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