一个预测模型的代谢综合征在一个以社区为基础的人群睡眠呼吸暂停:二次预防查工具使用简单和可访问的指标
Tong Feng1, Qiong Ou2, Guangliang Shan3
1Department of Respiratory and Critical Care Medicine, Deyang People's Hospital, Deyang, China.
Frontiers in nutrition
|November 21, 2025
概括
一个新的模型使用简单的阻塞性睡眠呼吸暂停 (OSA) 查指标预测代谢综合征 (MetS) 风险. 该工具允许个人独立评估他们的MetS风险,改善早期检测和预后.
科学领域:
- 心脏病学 心脏病学
- 公共卫生 公共卫生
- 数据科学数据科学数据科学
背景情况:
- 代谢综合征 (MetS) 对健康构成重大负担.
- 早期识别高风险的个人 MetS 对于二次预防至关重要.
- 阻塞性睡眠呼吸暂停 (OSA) 越来越多地被认为是MetS的潜在风险因素.
研究的目的:
- 使用基于社区的OSA查数据,开发MetS的预测模型.
- 确定用于早期 MetS 风险评估的简单,可访问的指标.
- 促进居民独立评估风险,减少对复杂诊断的依赖.
主要方法:
- 招募了中国新诊断的OSA成年人队列.
- 最小绝对收缩和选择运算符 (LASSO) 回归确定了关键预测变量.
- 训练和评估了9个机器学习算法,包括后勤回归和随机森林.
- 使用AUC-ROC,精度,灵敏度,特异性,F1得分,校准曲线和临床决策曲线分析 (DCA) 来评估模型性能.
- 沙普利添加式解释 (SHAP) 分析增强了模型的解释性.
主要成果:
- 后勤回归模型在测试数据集上表现出优异的性能,AUC为0.814.
- 确定的主要预测因素是体重指数 (BMI),年龄和性别.
- 该模型实现了高灵敏度 (0.794) 和特异性 (0.647),精度为0.693.
- 外部验证证实了该模型的稳定性,AUC为0.818.
- 校准曲线和DCA证实了模型的临床实用性和可靠性.
结论:
- 使用基于社区的OSA查数据,成功开发了一种可靠的MetS预测模型.
- 该模型使用简单的,自我报告的指标,使得独立的风险评估.
- 这种工具可以作为一种主要的查方法,用于早期发现和预防MetS.
相关概念视频
Sleep Apnea
456
Sleep apnea is a condition where breathing stops intermittently during sleep, often leading to significant health issues. Each episode can last from 10 to 20 seconds or more and is frequently accompanied by a brief arousal from sleep. This disturbance, largely unnoticed by the individual, can lead to severe daytime fatigue. Commonly, individuals seek help after being informed by their partners about loud snoring and noticeable breathing pauses during sleep.
The condition is more prevalent among...
The condition is more prevalent among...
456
Insufficient Sleep and Sleep Deprivation
812
Insufficient sleep refers to not getting the recommended amount of sleep for optimal functioning, even if it's just slightly less than needed. Sleep insufficiency may occur due to lifestyle choices, such as staying up late for social events or work, resulting in routinely getting less sleep than required. For example, consistently sleeping 6 hours when the body needs 7-9 hours can lead to cumulative effects on health and well-being.
Sleep deprivation is a more severe form of sleep loss...
Sleep deprivation is a more severe form of sleep loss...
812
Coronary Artery Disease I: Introduction
857
Coronary Artery Disease (CAD): An Overview with Scientific InsightsCoronary Artery Disease (CAD), often referred to as C-A-D, is a prevalent blood vessel disorder classified under the broader category of atherosclerosis. Atherosclerosis is a pathological process characterized by the hardening and narrowing of arteries due to the accumulation of atherosclerotic plaques. These plaques are composed of cholesterol, fatty substances, inflammatory cells, calcium, and fibrin, reducing blood flow to...
857
Substance Use Disorders Affecting Sleep
381
Substance use disorders involve a pattern of using drugs more extensively than intended and continuing use despite harmful consequences. This includes legal substances like alcohol and nicotine, as well as illegal drugs. These disorders often involve both physical and psychological dependence, reflecting compulsive use of substances that significantly alter thoughts, feelings, and behaviors, contributing to a major public health issue.
Understanding the concepts of physical dependence,...
Understanding the concepts of physical dependence,...
381


