改变Staphylococcus aureus在无氧性皮肤炎中的耐药性:来自英国一项区域研究对局部抗菌剂使用的含义
Bilal Amer Mian1, Aiden J Plant2
1Department of Microbiology, Walsall Healthcare NHS Trust, Walsall, GBR.
Cureus
|November 21, 2025
概括
在皮肤感染中发现了高水平的抗甲素黄金葡萄球菌 (MRSA) 和酸耐药性. 这凸显了需要重新考虑在阿托皮性皮肤炎管理中局部使用酸的必要性.
科学领域:
- 皮肤病学 皮肤病学
- 传染性疾病 传染性疾病
- 微生物学 微生物学
背景情况:
- 黄金葡萄球菌 (Staphylococcus aureus) 在亚托皮性皮肤炎的发病和恶化中起着核心作用.
- 抗微生物药物耐药性需要了解局部易感性模式,以获得有效的治疗和管理.
- 超级感染S. aureus复杂化了阿托皮性皮肤炎的管理.
研究的目的:
- 分析来自英国黑国 (2019-2024) 皮肤感染的黄金葡萄球菌分离物的抗微生物敏感性模式.
- 为了比较社区和医院隔离体之间的耐药性流行率,以及儿科和成人群体之间的耐药性流行率.
- 评估对关键抗生素的耐药性,包括酸,红红素,克林达胺素和四环素.
主要方法:
- 从皮肤和软组织感染中分离的金黄色细菌的回顾性分析.
- 被归类为社区 (全科医院) 或医院 (住院/门诊) 的隔离物.
- 进行了抗微生物敏感性测试;耐甲基黄金色杆菌 (MRSA) 通过流沙/氧沙耐药性来定义. 用于比较的基平方测试.
主要成果:
- 社区隔离的MRSA总体患病率为7%,医院隔离的患病率为11%.
- 儿科隔离物显示MRSA患病率为10%,与成年人没有显著差异 (p=0.47).
- 儿童 (21%) 与成年人 (14%,p=0.002) 之间的酸耐药性显著更高. 成年人对红色素,克林达米辛和四环素的耐药性更高.
结论:
- 这项研究揭示了皮肤病学S. aureus分离物中令人担忧的高MRSA和酸耐药性.
- 在儿童中增加的酸耐药性要求重新考虑其在亚托皮性皮肤炎的局部使用.
- 皮肤病学为主导的抗菌药物管理对于打击社区对黄金色杆菌感染的抗药性升级至关重要.
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