心脏移植接受者在移植后体外膜氧化 (ECMO) 时感染的发生率和危险因素
Lorena van den Bogaart1,2,3, Mario Fernández-Ruiz4,5,6, Linard D Hoessly7
1Transplantation Center, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland.
Transplantation direct
|November 21, 2025
概括
心脏移植后使用体外膜氧化 (ECMO) 会增加整体和真菌感染的风险. 需要进一步的研究来确定ECMO是否会独立引起感染或表明病情更严重的患者.
科学领域:
- 心脏病学 心脏病学
- 传染性疾病 传染性疾病
- 移植医学 移植医学
背景情况:
- 体外膜氧化 (ECMO) 在移植后使用,但其与传染性并发症的关联需要调查.
- 评估ECMO对心脏移植患者感染率的影响对于患者的治疗结果至关重要.
研究的目的:
- 评估心脏移植后ECMO使用对心脏移植接受者的传染病发病率的影响.
- 为了确定与心脏移植患者感染相关的风险因素,按病原体群分层.
主要方法:
- 一项全国性的队列研究包括306名心脏移植接受者从2008-2017年.
- 计算了移植后1年感染的发病率.
- 使用考克斯回归分析来确定与感染相关的风险因素.
主要成果:
- 42名患者 (13.7%) 接受了移植后的ECMO.
- 在ECMO组中,总体发病率 (259vs126每100个患者年) 和真菌感染 (36vs14每100个患者年) 的发病率较高.
- 使用ECMO显着与整体感染 (HR 1.81) 和真菌感染 (HR 3.44) 的风险增加有关.
结论:
- 心脏移植后ECMO在心脏移植接受者的使用与整体和真菌感染的风险更高有关.
- 需要进行进一步的研究,以确定ECMO是否是感染的独立风险因素或患者严重性的标志物.
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