扎勒普隆纳米塑料装载的皮肤贴片:配方,优化,活体透和活体研究
Ahmed A El-Shenawy1,2, Reham A Abd Elkarim3, Reda A Mahmoud1,2
1Department of Pharmaceutics and Pharmaceutical Technology, Faculty of Pharmacy, Al-Azhar University, Assiut, Egypt.
概括
这项研究开发了用于Zaleplon (ZLP) 通过皮肤输送的新型spanlastic纳米囊,显著提高了其生物可用性. 这些装有ZLP的皮肤贴片为失眠治疗提供了一个有希望的替代方案.
科学领域:
- 制药科学 制药科学
- 药物输送系统 药物输送系统
- 纳米技术纳米技术
背景情况:
- 扎莱普隆 (ZLP) 由于溶解度低和肝脏代谢广泛,具有较差的口服生物利用性.
- 通过皮肤传递提供了一种潜在的途径,以克服ZLP的药理动力学限制.
研究的目的:
- 通过封装在塑料纳米丝片中增强扎勒 (ZLP) 的生物利用性.
- 为改善失眠治疗开发和描述带有ZLP的spanlastic透皮贴片.
主要方法:
- 用ZLP装载的钢筋塑料是使用薄膜水化技术制造的,并通过3 ^ 2全因数设计进行优化.
- 使用溶剂造技术,优化塑料被纳入HPMC K100M透皮贴片中.
- 配方的特点是囊泡大小,捕获效率,药物释放,皮肤透,稳定性和体内药理学.
主要成果:
- 优化塑料是纳米大小 (297.2 ± 8.17 nm) 的,具有高捕获效率 (65.75 ± 3.28%) 和持续24小时释放 (76.44 ± 5.66%).
- 透皮贴片表现出均的药物含量和显著增强的ZLP透 (3.62倍以上的稳定状态流量).
- 在体内研究表明,与口服悬浮剂相比,spanlastic通过皮肤贴片的相对生物利用率为2.681%.
结论:
- 制造的ZLP装载的spanlastic纳米纤维和皮肤贴片为改善ZLP生物可用性提供了一个可行的策略.
- 开发的透皮系统显示了对失眠的有效和增强治疗的潜力.
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