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肌肉功能调解了维生素D缺乏和关节骨折风险之间的关联:老年人的回顾性研究
Xiongyi Wang1, Yutong Hu1, Simin Yun1
1Department of Orthopaedics, Second Affiliated Hospital of Soochow University, Osteoporosis Research Institute of Soochow University, Suzhou, China.
Frontiers in endocrinology
|November 21, 2025
概括
维生素D缺乏会增加关节骨折的风险,主要是通过削弱肌肉功能,而不是骨密度. 这凸显了评估肌肉强度以及维生素D水平对于预防老年人骨折的重要性.
科学领域:
- 老年学是一门学科.
- 骨健康 骨健康 骨健康
- 肌肉骨健康 肌肉骨健康
背景情况:
- 关节骨折是老年人群发病和死亡的主要原因.
- 维生素D对骨矿物质密度 (BMD) 的作用已经确立,但其对肌肉功能和骨折风险的影响不太清楚.
研究的目的:
- 调查维生素D缺乏是否会增加关节骨折的风险,特别是通过其对肌肉功能的影响.
主要方法:
- 一项回顾性研究比较了138名关节骨折患者 (≥50岁) 与182名对照患者 (≥50岁).
- 评估了维生素D,部部 BMD (FN aBMD) 和胸部肌肉指数 (PMI) 的肌肉功能.
- 回归分析确定了关节骨折的独立风险因素.
主要成果:
- 骨折患者的BMI,维生素D,肌肉功能 (PMI) 和FN aBMD比对照人群低.
- 维生素D,PMI和FN aBMD是独立的保护因素,防止关节骨折.
- 维生素D缺乏与肉症有关;维生素D没有显著影响骨质疏松症.
结论:
- 维生素D缺乏会增加关节骨折的风险,主要是通过肌肉功能受损,而不仅仅是减少了BMD.
- 维生素D补充对于老年人来说至关重要;将肌肉功能评估纳入骨折预防中至关重要.
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