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可喷的水凝海绵用于神经血管微环境重建和糖尿病伤口愈合中的炎症调节

Xiaozhen Zhou^1,2,3, Pengchao Ma⁴, Yihao Liu^4,5

¹Department of Plastic and Aesthetic Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100032, China.

Bioactive materials

|November 21, 2025

概括

一种新型的喷式水凝海绵通过重建神经血管微环境并减少炎症,有效促进糖尿病伤口愈合. 这种先进的敷料增强了血管和神经的再生,以更好地修复组织.

科学领域:

生物材料科学生物材料科学
再生医学是一种再生医学.
伤口愈合治愈伤口愈合

背景情况:

糖尿病伤口表现出神经血管功能受损和慢性炎症,阻碍组织再生.
目前用于糖尿病伤口神经血管修复的治疗策略有限.
重建神经血管微环境对于有效的糖尿病伤口管理至关重要.

研究的目的:

开发一种可喷的水凝海绵 (S-GPL),其功能与血管内皮生长因子模仿性 (KLT) 和来自大脑的神经营养因子模仿性 (RGI) 相配合.
评估水凝在重建神经血管微环境和促进糖尿病伤口愈合方面的有效性.
为了研究水凝对慢性炎症的免疫调节作用.

主要方法:

制造可喷的水凝海绵 (S-GPL) 从凝甲基和修饰的e-多聚-L-素.
水凝与KLT和RGI的共同功能化.
在体外评估内皮细胞和施万细胞反应和细胞间通信.
在老鼠全厚糖尿病伤口模型中的体内评估,包括伤口关闭,组织学分析和新血管化和轴突再生的评估.
转录和免疫组织化学分析以调查抗炎作用.

主要成果:

可喷的水凝 (S-GPL^KLT/RGI) 显示出增强的排泄物吸收和持续的释放.
实验室研究表明,KLT促进了内皮细胞成熟,RGI增强了施万细胞活性,促进了神经血管通信.
在体内,S-GPL^KLT/RGI加速了伤口关闭,重新表皮化和矩阵重塑.
观察到新血管化和轴突再生的显著增强,形成了一个有组织的神经血管利基.
水凝抑制了IL-17信号通路,表明它具有抗炎性质.

结论:

开发的可喷的水凝海绵有效地重建了糖尿病伤口中的神经血管微环境.
S-GPL^KLT/RGI通过增强的新血管化和轴突再生促进加速伤口愈合.
水凝具有内在的抗炎性质,减轻与糖尿病伤口相关的慢性炎症.
这种可喷的抗菌水凝为管理复杂的糖尿病伤口提供了一种临床可转换的策略.

关键词:

糖尿病人的伤口包裹.凝海绵是一种水凝海绵.炎症调制是指调节炎症的过程.神经血管微环境的神经血管微环境可以喷的水凝.

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