在瘤治疗中用于线粒体向和生物能量干扰的Jahn-Teller扭曲工程自行推进的纳米机器人
Tianying Luo1,2, Mingyi Zhang1, Jia Xu1
1Department of Biotherapy, Cancer Center and State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, 610041, China.
Bioactive materials
|November 21, 2025
概括
自动化纳米机器人为线粒体提供化疗,产生氧气以增强瘤透和抑制. 实时成像追踪纳米机器人活动,用于精确的癌症治疗.
科学领域:
- 生物医学工程 生物医学工程
- 纳米技术纳米技术
- 癌症治疗 癌症治疗
背景情况:
- 线粒体代谢对于瘤生长至关重要.
- 目前的疗法面临着组织透和控制方面的挑战.
- 准线粒体为癌症治疗提供了一个有希望的策略.
研究的目的:
- 为增强瘤治疗开发自行驱动的纳米机器人.
- 整合氧气生成,向线粒体的药物输送和成像.
- 为了实现精确的,空间时间控制的癌症治疗.
主要方法:
- 制造 Jahn-Teller 扭曲工程纳米机器人 (IDP@Z@AP).
- 在ZIF-8.8中同时封装光热剂 (IR1048) 和药物 (DOX-TPP).
- 定AuPt双金属纳米酶用于催化活性.
- 使用NIR-II激光器进行光热增强和成像.
主要成果:
- 纳米机器人表现出增强的葡萄糖氧化酶和酶类活动.
- 自主运动和内氧气生成促进了深度瘤透.
- 有效的线粒体向导致ATP耗尽并抑制癌细胞入侵.
- 3D NIR-II PA成像允许实时监控纳米机器人生物分布和氧气生成.
结论:
- 纳米机器人平台有效调节瘤缺氧.
- 增强化疗向线粒体的输送实现了强大的瘤抑制.
- 这种策略为细胞下癌症治疗提供实时反.
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