严重的酒精使用和COVID-19:对身体和心理健康的影响
Javier Calleja-Conde1,2,3, Víctor Echeverry-Alzate3, Sara Sánchez-Diez2
1Cardenal Cisneros Higher Education Center, Madrid, Spain.
Frontiers in psychiatry
|November 21, 2025
概括
慢性饮酒会通过削弱免疫反应和增加神经炎症,使COVID-19的结果变得更糟. 将酒精使用障碍纳入护理是管理SARS-CoV-2感染和长期COVID的关键.
科学领域:
- 免疫学 免疫学 免疫学
- 神经科学是一个神经科学.
- 传染性疾病 传染性疾病
背景情况:
- 随着COVID-19的蔓延,已经突出了患有先前疾病的个体的脆弱性,包括物质使用障碍.
- 慢性酒精消费是一个被忽视的因素,可能会加剧SARS-CoV-2感染的严重程度和长期影响.
研究的目的:
- 审查酒精使用与COVID-19之间的生物和临床联系.
- 探索免疫功能障碍,神经炎症和肠-大脑轴障碍的共同机制.
主要方法:
- 现有科学文献的叙述性审查.
- 综合了关于免疫反应,细胞因子信号传递和屏障完整性的发现.
- 对宿主易感性,疫苗接种反应和神经精神症状的影响分析.
主要成果:
- 酒精使用和SARS-CoV-2感染都会损害先天性和适应性免疫力,并破坏肠-大脑轴.
- 共同的通路涉及改变的细胞因子信号传递和削弱的粘膜和血脑屏障.
- 慢性酒精使用可能会增加对感染的易感性,并影响疫苗反应,影响恢复和长期COVID风险.
结论:
- 酒精使用障碍通过共享的生物学途径加剧了COVID-19的严重程度和长期COVID症状.
- 将酒精使用障碍纳入COVID-19风险评估和管理是必不可少的.
- 需要采取多学科的方法来解决酒精,免疫力和病毒感染之间的复杂相互作用.
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