高效封装和pH触发释放的dcetaxel从叶酸功能化的ZIF-90纳米载体
Rizgar Noori1, Nian N N Maarof2,3, Azad H Alshatteri4
1Department of Chemistry, College of Science, Charmo University Chamchamal Kurdistan Region 46023 Iraq Iraq.rzgar.nory@chu.edu.iq.
RSC advances
|November 21, 2025
概括
叶酸修饰的化物伊米达酸框架-90 (ZIF-90) 纳米颗粒有效地为乳腺癌治疗提供多塞塔克塞尔 (DTX). 这些响应pH的纳米载体在酸性瘤环境中表现出增强的药物释放,并有针对性地向癌细胞输送.
科学领域:
- 材料科学 材料科学 材料科学
- 纳米技术纳米技术
- 生物医学工程 生物医学工程
背景情况:
- 金属有机框架 (MOF) 具有高孔隙性和可调节的结构,适合药物输送.
- 氧化伊米达酸框架-90 (ZIF-90) 提供化基以实现功能化和提高生物相容性.
- 多塞 (DTX) 是乳腺癌治疗的关键化疗剂.
研究的目的:
- 开发叶酸结合的ZIF-90纳米颗粒作为dcetaxel的pH响应药物递送系统.
- 评估纳米载体的封装效率,药物载荷能力和体外释放特征.
- 评估ZIF-90与ZIF-8在药物输送和向癌症治疗方面的优势.
主要方法:
- 用叶酸修饰的ZIF-90纳米颗粒的合成和表征.
- 在ZIF-90纳米载体中封装dcetaxel (DTX).
- 在不同pH值 (5.5和7.4) 的体外药物释放研究.
- 使用希克森-克劳尔和科尔斯迈耶-佩帕斯模型对药物释放的动态建模.
主要成果:
- 实现了高封装效率 (92.8%) 和药物装载能力 (8.43%).
- 纳米载体表现出pH响应的药物释放,在酸性pH (5.5) 释放更快,在生理pH (7.4) 持续释放.
- 药物释放动力学最好用希克森-克劳尔和科尔斯迈尔-佩帕斯模型来描述,表明表面侵蚀和异常扩散.
- 叶酸结合增强了针对叶酸受体过度表达乳腺癌细胞的向特异性.
结论:
- 叶酸功能化的ZIF-90纳米颗粒作为dcetaxel的高效,pH响应的载体.
- 与ZIF-8相比,ZIF-90在稳定的结合和酸性可降解方面具有优势,提高了药物输送.
- 这一平台显示了针对性乳腺癌治疗的巨大潜力,需要进一步进行生物评估.
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