基于声心图的冠状动脉疾病预测模型 (CAD-score系统) 的诊断性能:系统性审查和元分析
Miftah Pramudyo1,2, Ahmad Faried2,3, Mohammad Rizki Akbar1,3
1Department of Cardiology and Vascular Medicine, Faculty of Medicine, Universitas Padjadjaran, Bandung, Indonesia.
Frontiers in cardiovascular medicine
|November 21, 2025
概括
使用CADScor®系统的心电图 (PCG) 显示出排除冠状动脉疾病 (CAD) 的潜力. 这一元分析发现PCG是非侵入性CAD评估的有希望的工具.
科学领域:
- 心脏病学 心脏病学
- 医疗器械 医疗器械
- 诊断的准确性 诊断的准确性
背景情况:
- 阻塞性冠状动脉疾病 (CAD) 的测试前概率分层仍然低于最佳.
- 目前对CAD的诊断测试经常产生正常结果,导致效率低下.
- 测量冠状动脉狭窄引起的微噪声的声学设备显示出CAD分层的前景.
研究的目的:
- 调查声心图 (PCG) 在检测冠状动脉疾病 (CAD) 中的诊断价值.
- 通过元分析评估CADScor®系统在预测CAD方面的准确性.
主要方法:
- 在PubMed,EuropePMC和ScienceDirect上进行了系统的文献搜索,截至2025年1月.
- 符合条件的研究评估了PCG的准确性,使用CADScor®系统进行CAD预测.
- 来自4项涉及4050名患者的研究的数据被纳入了元分析.
主要成果:
- 对PCG的综合敏感度为87% (95%CI,80%-92%),特异性为35% (95%CI,21%-52%).
- 聚合的负概率比 (NLR) 为0.37 (95% CI,0.25-0.55),表明作为排除测试的实用性.
- 在ROC曲线下的面积 (AUC) 为0.79 (95% CI,0.75-0.82),表明良好的区分能力.
结论:
- 声心图 (PCG) 显示出作为疑似冠状动脉疾病 (CAD) 患者有效排除工具的潜力.
- 使用PCG的CADScor®系统可以帮助非侵入性地评估CAD的可能性.
相关概念视频
01:25Imaging Studies for Cardiovascular System VI: Calcium -Scoring CT
374
Calcium-Scoring CT ScanA calcium-scoring CT scan, also known as coronary artery calcium (CAC) scan, detects calcium deposits in the coronary arteries. This test assesses the risk of coronary artery disease (CAD), which can lead to cardiovascular events such as angina, heart failure, and sudden cardiac arrest.A calcium-scoring CT scan is generally recommended for individuals at intermediate risk of CAD without symptoms. It includes:Men aged 40-75 and women aged 50-75: Especially those with a...
374
01:30Acute Coronary Syndrome III: Diagnostic Studies
200
Diagnosing acute coronary syndrome or ACS begins with a thorough patient history. Notable symptoms include central, crushing chest pain radiating to the left arm, neck, jaw, or back, along with shortness of breath, sweating (diaphoresis), nausea, vomiting, dizziness, and palpitations.It is crucial to note any history of cardiac illnesses and assess risk factors, including age, gender, smoking, hypertension, diabetes, hyperlipidemia, and a sedentary lifestyle.During physical examination, vital...
200
01:30Coronary Artery Disease I: Introduction
857
Coronary Artery Disease (CAD): An Overview with Scientific InsightsCoronary Artery Disease (CAD), often referred to as C-A-D, is a prevalent blood vessel disorder classified under the broader category of atherosclerosis. Atherosclerosis is a pathological process characterized by the hardening and narrowing of arteries due to the accumulation of atherosclerotic plaques. These plaques are composed of cholesterol, fatty substances, inflammatory cells, calcium, and fibrin, reducing blood flow to...
857
01:28Imaging Studies for Cardiovascular System V: CT
264
Cardiac computed tomography (CT) scanning is an advanced cardiac imaging technique that utilizes CT technology, with or without intravenous (IV) contrast, to produce accurate cross-sectional virtual slices of specific areas of the heart, coronary circulation, and major blood vessels such as the aorta, pulmonary veins, and arteries. The computer processes these slices to generate three-dimensional images. Multidetector CT (MDCT) is a rapid form of CT scanning that captures multiple slices...
264
01:26Coronary Artery Disease IV: Preventive Measures
577
Effective preventive measures for coronary artery disease (CAD) focus on controlling modifiable risk factors, including cholesterol abnormalities and lifestyle changes.Cholesterol ManagementFirst, the Mediterranean diet and the American Heart Association advocate for maintaining low-density lipoprotein (LDL) cholesterol levels below 100 mg/dL, with a more stringent recommendation of below 70 mg/dL for individuals at high risk. LDL cholesterol, often termed "bad cholesterol," can lead to the...
577
01:27Coronary Artery Disease V: Interprofessional Care
206
Interprofessional care for coronary artery disease includes pharmacological therapy and revascularization procedures.Pharmacological therapy for Coronary Artery Disease (CAD) aims to manage symptoms, prevent complications, and improve patient outcomes through various classes of medications:Antiplatelet Agents:Aspirin and Clopidogrel: These medications inhibit platelet aggregation, preventing blood clots, which is crucial for avoiding heart attacks and strokes. Doctors often prescribe these...
206