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虫感染调节了叙利亚仓鼠对SARS-CoV-2的肺部和肠道转录基因反应

Bruce A Rosa¹, Mahdiyeh Bigham¹, Tamarand L Darling¹

¹Division of Infectious Diseases, Department of Medicine, Washington University School of Medicine, St. Louis, MO, United States.

Frontiers in immunology

|November 21, 2025

概括

以前的虫感染重塑了宿主对SARS-CoV-2的反应,增强了肺部免疫力和肠道炎症. 这种免疫调节可能解释了虫流行地区COVID-19严重程度的降低.

科学领域:

免疫学免疫学免疫学
传染性疾病传染性疾病
基因组学就是基因组学.

背景情况:

虫感染在资源有限的环境中很常见,并且可以改变宿主免疫反应.
肠道虫对包括SARS-CoV-2在内的呼吸道病毒敏感性的影响尚不清楚.
调查虫-SARS-CoV-2共感染提供了对宿主-病原体相互作用和免疫调节的见解.

研究的目的:

调查之前虫 (Ancylostoma ceylanicum) 感染对宿主对SARS-CoV-2的反应的影响.
为了比较与虫和SARS-CoV-2共感染的叙利亚仓鼠的组织特异性转录反应.
为了确定虫诱导的SARS-CoV-2感染结果调节的基础分子机制.

主要方法:

叙利亚仓鼠感染了虫,SARS-CoV-2,或两者,与天真对照一起.
病毒标位和体重减轻在感染后被评估.
用RNA测序 (RNA-seq) 在多个时间点分析肺部和肠道组织的转录形状.

主要成果:

与单独的SARS-CoV-2相比,联合感染并没有显著改变病毒标位或体重减轻.
在共感染的动物中观察到明显的转录特征,肺部B细胞相关基因表达增强,肠道炎症相关基因增加.
虫感染减弱了肺部的关键SARS-CoV-2响应基因和途径,包括计费类受体信号和COVID-19严重程度和长期COVID的生物标志物.

结论:

安西洛斯托马西兰菌感染以组织特异的方式重塑宿主对SARS-CoV-2的转录反应.
虫诱导的免疫调节减弱了SARS-CoV-2特异性反应,可能有助于减少在虫流行地区观察到的疾病严重程度.
这些发现为了解虫-SARS-CoV-2相互作用及其与其他呼吸道病毒感染的相关性提供了分子框架.

关键词:

这就是SARS-CoV-2病毒.共同感染是一种共感染.虫病毒的相互作用虫虫是一种虫.主机响应的主机响应.免疫调节的免疫调节翻译学翻译学翻译学翻译学

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