双边同步多重原发性肺癌患者的长期结果和最佳时间间隔之间的关系:一个多机构队列研究
Wei Guo1,2, Bolun Zhou1, Qilin Huai1
1Department of Thoracic Surgery, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, People's Republic of China.
Annals of medicine
|November 21, 2025
概括
对于同步多重原发性肺癌 (sMPLC),手术间隔显著影响结果. 90至180天的最佳手术时间可以改善患者的预后并减少并发症.
科学领域:
- 胸部外科手术 胸部外科手术
- 手术瘤学手术瘤学
- 肺部医学 肺部医学
背景情况:
- 由于诊断技术的进步和环境变化,同步多重原发性肺癌 (sMPLC) 的发病率不断增加.
- 需要了解手术时间对sMPLC患者临床结果的影响.
研究的目的:
- 研究两次手术时间间隔与双边sMPLC患者的临床结果之间的相关性.
- 确定最佳的手术时间,以改善sMPLC的预后.
主要方法:
- 对901名双边sMPLC患者进行了两次手术的回顾性多机构队列研究 (2017年1月至2022年12月).
- 患者根据手术间隔分为三个组:≤90天 (I组),90-180天 (II组) 和>180天 (III组).
主要成果:
- 手术之间的间隔显著影响了整体存活率 (OS) 和无病存活率 (DFS) (p<0.0001).
- 与I组和III组相比,II组 (90-180天) 的结果更为有利.
- 第一组与肺功能减弱有关,而第三组患术后并发症的发病率较高.
结论:
- 第一次和第二次手术之间的90至180天的手术间隔似乎对双边sMPLC患者来说是最有益的.
- 手术时间是影响sMPLC管理中预后和术后结果的关键因素.
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