长期死亡率和第一发精神病的相关因素:一项25年后续研究
Chao Li1, Wing Tse1, Sin Ting Chu1
1Department of Psychiatry, Li Ka Shing Faculty of Medicine, https://ror.org/02zhqgq86The University of Hong Kong, Hong Kong SAR, China.
Psychological medicine
|November 21, 2025
概括
第一发精神病 (FEP) 患者的死亡率很高,随着时间的推移,风险会发生变化. 整合身体和个性化护理对于降低精神疾病过度死亡率至关重要.
科学领域:
- 精神病学和公共卫生
- 流行病学 流行病学
- 临床心理学 临床心理学
背景情况:
- 患有第一发精神病 (FEP) 的个人经历的死亡率明显更高.
- 长期死亡率趋势和FEP队列中的贡献因素尚未得到充分了解.
- 这项研究调查了25年来FEP队列中的死亡率模式和相关因素.
研究的目的:
- 在第一发精神病 (FEP) 队列中检查长期死亡模式和标准化死亡率 (SMR).
- 确定与全因,自然和非自然死亡相关的社会人口学,临床和治疗相关因素.
- 了解特定阶段的死亡风险,并为患有精神病的人提供有针对性的干预措施.
主要方法:
- 一项基于人口的队列研究追踪了1389名FEP患者,长达25年.
- 死亡率数据来源于中央医院数据库和验尸官报告.
- 统计分析检查了基线特征,治疗因素和死亡结果之间的关联.
主要成果:
- 总共有137例死亡 (9.86%) 发生,总体SMR为6.56.
- 不自然死亡风险在前10年急剧增加;自然死亡风险在第一个十年后上升.
- 男性性别,较差的社会功能,较低的教育程度,基线住院和抗精神病药物可变性与增加的死亡风险有关.
结论:
- 在FEP中死亡率模式在25年内演变,表明需求不断变化.
- 将身体健康保健纳入心理健康服务是必不可少的.
- 特定阶段和个性化的护理可以帮助减少精神病障碍的长期过度死亡率.
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