[在固体器官移植中进行疫苗接种]
Sebastian Rask Hamm1, Christina Ekenberg2, Hans Henrik Lawaetz Schultz3
1Afdeling for Infektionssygdomme, Københavns Universitetshospital - Rigshospitalet.
Ugeskrift for laeger
|November 21, 2025
概括
建议对实体器官移植 (SOT) 候选人进行疫苗接种. 尽管免疫反应较弱,但接种疫苗的SOT接种者患重症感染和相关疾病的风险较低.
科学领域:
- 免疫学 免疫学 免疫学
- 移植医学 移植医学 移植医学
- 预防传染病 预防传染病
背景情况:
- 固体器官移植 (SOT) 接受者需要免疫抑制疗法,增加他们对感染的脆弱性.
- SOT接种者接种疫苗的反应往往比一般人群弱.
- 国际和丹麦的指导方针建议对SOT候选人进行移植前疫苗接种.
研究的目的:
- 审查SOT接种者接种疫苗的证据.
- 评估疫苗接种与SOT接种者的严重感染相关疾病之间的关联.
- 评估国家疫苗接种计划对SOT候选人的影响.
主要方法:
- 对SOT接种者接种疫苗的现有文献进行系统审查.
- 分析丹麦国家疫苗接种计划中对SOT候选人的数据.
主要成果:
- SOT接种者的疫苗接种与严重感染相关疾病的风险降低有关.
- 尽管免疫反应减弱,但疫苗的保护作用是显而易见的.
- 丹麦国家疫苗接种计划对SOT候选人的疫苗接种覆盖率很高.
结论:
- 移植前接种疫苗是减轻SOT接受者感染风险的关键策略.
- 疫苗接种计划有效地改善了SOT候选人中的疫苗接种率.
- 进一步的研究可能会探索优化免疫功能低下人群的疫苗策略.
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