细菌CipB是一种外源性受体,可以驱动线性-TFEB轴,并促进病变发生
Shuai Liu1,2, Lina Ma1, Ruiqi Lv1
1State Key Laboratory of Agricultural Microbiology, College of Life Science and Technology, College of Biomedicine and Health, Huazhong Agricultural University , Wuhan, China.
The Journal of cell biology
|November 21, 2025
概括
这项研究确定了 CipB,一种细菌蛋白质,作为一种新型的菌受体,有助于病原体逃避免疫反应. CipB操纵宿主线粒细胞分裂以促进细菌的生存和毒性.
科学领域:
- 细胞生物学 细胞生物学
- 微生物学 微生物学
- 免疫学 免疫学 免疫学
背景情况:
- 线粒体对于细胞平衡至关重要,通过降解线粒体来调节能量,炎症和免疫力.
- 病原体通常会发展出机制,以颠覆宿主细胞过程,以造福自身.
研究的目的:
- 确定细菌病原体使用的新型外源性线粒细胞受体.
- 阐明细菌效应器操纵宿主线粒细胞因生病的机制.
主要方法:
- 鉴定CipB作为一种来自Chromobacterium violaceum的III型分泌系统 (T3SS) 效应剂.
- 通过LC3交互区域 (LIR) 基因,研究CipB与线粒体蛋白TUFM和自胞体的相互作用.
- 使用小鼠模型评估CipB在细菌殖民和毒性中的作用.
主要成果:
- CipB作为外源性线粒体受体起作用,准线粒体并启动线粒体-TFEB通路.
- CipB触发TFEB核转位,抑制促炎性细胞因子,并促进细菌的存活和发病.
- CipB的线粒细胞受体活性对于Chromobacterium violaceum在小鼠肝脏和脏中的殖民是必不可少的.
结论:
- 细菌病原体可以通过CipB等外源受体利用宿主线粒来抑制免疫反应.
- CipB代表了一种保存的T3SS效应器家族,可以操纵宿主线粒,突出显示了一种新的毒性策略.
- 线性菌-TFEB轴是治疗细菌感染的潜在目标.
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