齐利尼迪平立方体纳米凝贴片:聚合物-纳米结构协同作用,用于先进的通过皮肤递送药物
Cleona Elizabeth Mary DCruz1, Lalit Kumar2, Liesl Maria Fernandes E Mendonça3
1Department of Pharmaceutics, Goa College of Pharmacy, Goa University, 18th June Road, Panaji, Goa, 403001, India.
Naunyn-Schmiedeberg's archives of pharmacology
|November 21, 2025
概括
这项研究开发了cilnidipine立方体纳米凝贴片用于通过皮肤输送,显著增强药物透和释放. 创新的贴片提供了一种安全有效的方法,通过皮肤治疗高血压.
科学领域:
- 制药科学 制药科学
- 纳米技术 纳米技术
- 药物输送系统 药物输送系统
背景情况:
- 抗高血压药物的溶解性和生物可用性差,需要先进的输送系统.
- 立方体,基于脂质的纳米结构颗粒,提供更好的药物溶解性和皮肤透性.
- 透皮药物输送系统为全身药物管理提供了一个非侵入性的替代方案.
研究的目的:
- 开发和评估基尼迪平立体纳米凝贴片 (CLD CB NGP) 以提高通过皮肤递送药物的效果.
- 使用Box-Behnken设计优化CLD载荷立方体,以改善药物载荷和稳定性.
- 评估纳米凝贴片在持续药物释放和皮肤透方面的体外和体外性能.
主要方法:
- 通过自上而下的方法准备的CLD载荷立方体,并使用Box-Behnken设计进行优化.
- 用粒子大小,封装效率,泽塔潜力和形态学来表征立方体体.
- 使用水友聚合物制造纳米凝贴片的配方和物理,机械和药物释放性质的评估.
- 使用切除的老鼠皮肤进行ex vivo皮肤透研究,并通过皮肤刺激测试进行安全评估.
主要成果:
- 优化的CLD立方体表现出具有高封装效率 (80.8%) 和良好的体稳定性的多角纳米粒子 (430nm).
- 用FTIR,DSC和XRD证实了立方体体内的药物变形.
- CLD CB NGP表现出多孔表面,良好的胀,优良的生物粘合性,并且显著增强了体外释放和体外皮肤透 (增加了3.62倍).
- 与对照组相比,CLD CB NGP观察到较高的稳定状态流量 (Jss = 0.377 mg/cm2/h),与对照组相比 (Jss = 0.104 mg/cm2/h).
- 皮肤刺激性研究和组织学证实了贴片的安全性和非刺激性.
结论:
- 奇利尼迪平立体纳米凝贴片代表了通过皮肤递送药物的创新方法.
- 开发的系统增强了药物的透性,治疗疗效,并提供持续释放.
- 集成到纳米凝贴片中的立方体提供了一个有希望的策略,以克服难溶性抗高血压药物的局限性.
相关概念视频
Drug Delivery: Miscellaneous Routes
697
Drug delivery methods like oral inhalation, nasal sprays, transdermal patches, eye drops, intravitreal injection, and rectal administration provide localized effects with reduced toxicity.
Oral inhalation and nasal sprays swiftly transfer drugs across the respiratory epithelium's mucosal layer. Inhaled glucocorticoids and bronchodilators directly target lung conditions such as asthma, while fluticasone nasal spray mitigates allergic rhinitis.
Transdermal patches transport drugs...
Oral inhalation and nasal sprays swiftly transfer drugs across the respiratory epithelium's mucosal layer. Inhaled glucocorticoids and bronchodilators directly target lung conditions such as asthma, while fluticasone nasal spray mitigates allergic rhinitis.
Transdermal patches transport drugs...
697
Drug Delivery: Overview
705
The selection of a drug's delivery route depends upon its physicochemical properties, including lipid or water solubility and ionization, as well as the therapeutic requirement, such as immediate or sustained effect. These routes can be divided into three primary categories: enteral, parenteral, and topical.
Enteral delivery involves administering drugs directly through swallowing, sublingual placement, or buccal application. Orally administered drugs predominantly navigate the...
Enteral delivery involves administering drugs directly through swallowing, sublingual placement, or buccal application. Orally administered drugs predominantly navigate the...
705
Drug Delivery: Enteral Route
1.5K
The enteral drug administration involves three primary routes: oral, sublingual, and buccal. Oral ingestion is the most prevalent, safe, economical, and convenient method for drug administration. However, it has certain drawbacks, including limited absorption due to the drug's low water solubility or poor membrane permeability, possible emesis from GI mucosa irritation, destruction of drugs by digestive enzymes or low gastric pH, and irregular absorption along with food or other drugs.
1.5K
Bioavailability Enhancement: Drug Permeability Enhancement
176
Body:After oral administration, poor permeability often limits the rate at which drugs are absorbed through the intestinal epithelium. Enhancing drug permeability is crucial for effective therapy, and several strategies have been developed to overcome this challenge.One effective strategy involves the use of lipid-based formulations. These formulations enhance dissolution and solubility, targeting physiological mechanisms to increase drug absorption. This includes stimulating bile salt...
176
Drug Delivery: Parenteral Route
1.5K
The parenteral route is a critical method of drug administration. It delivers compounds directly into the systemic circulation and bypasses the gastrointestinal tract. This approach is particularly advantageous for drugs that exhibit poor absorption or instability when administered orally.
There are three primary parenteral routes: intravenous (IV), intramuscular (IM), and subcutaneous (SC). The IV route introduces the drug directly into the bloodstream, ensuring immediate action. The IM route...
There are three primary parenteral routes: intravenous (IV), intramuscular (IM), and subcutaneous (SC). The IV route introduces the drug directly into the bloodstream, ensuring immediate action. The IM route...
1.5K
Factors Affecting Dissolution: Particle Size and Effective Surface Area
1.6K
Dissolution kinetics, an essential aspect of oral drug delivery, is significantly influenced by the drug's particle size. According to the Noyes-Whitney dissolution model, the dissolution rate correlates directly with the drug's surface area. The larger the surface area, the higher the drug's solubility in water, leading to a faster drug dissolution rate. Reducing particle size increases the effective surface area, enhancing the dissolution process. Micronization and nanosizing are...
1.6K


