拉曼光谱在骨关节炎中的预测性表现:系统性审查
Monira Yesmean1,2, Bijay Ratna Shakya3,4, Minna Mannerkorpi3
1Research Unit of Health Sciences and Technology, Faculty of Medicine, University of Oulu, Oulu, Finland. monira.yesmean@oulu.fi.
Journal of medical systems
|November 21, 2025
概括
拉曼光谱显示了早期骨关节炎检测的潜力,在临床前研究中实现了高精度. 然而,需要进一步的研究来解决偏见,并提高临床使用的概括性.
科学领域:
- 生物医学工程 生物医学工程
- 分子光谱学 分子光谱学
- 整形外科 整形外科 整形外科
背景情况:
- 骨关节炎 (OA) 的早期诊断对于有效干预至关重要,但缺乏可靠的方法.
- 拉曼光谱 (RS) 为OA的分子水平检测和监测提供了潜在的潜力.
- 目前的诊断工具在预测OA进展和严重程度方面存在局限性.
研究的目的:
- 系统评估拉曼光谱 (RS) 对人类样本骨关节炎 (OA) 评估的预测性能.
- 突出了RS在OA检测中的进步,并确定了RS的局限性.
- 评估RS在早期OA诊断和疾病监测方面的潜力.
主要方法:
- 在主要数据库 (PubMed,Scopus,Web of Science,IEEE) 的系统文献搜索,截至2024年7月31日.
- 由两名独立审稿人使用Covidence软件进行选和数据提取.
- 偏差风险和适用性评估使用预测模型偏差风险评估工具.
主要成果:
- 十项研究符合纳入标准,主要使用近红外激发的RS.
- 在临床前设置中,OA评估的预测准确度在73%至100%之间.
- 所有研究都经过内部验证,但大多数都表现出高偏差风险;没有报告外部验证.
结论:
- 拉曼光谱显示了早期OA检测和分子水平的评估的巨大潜力.
- 报告的高准确性受到方法学偏见和缺乏外部验证的限制.
- 未来的研究需要更大的队列,外部验证和标准化的临床翻译协议.
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