Jove
Visualize
联系我们

相关概念视频

Role of Neurotransmitters in Memory01:23

Role of Neurotransmitters in Memory

2.4K
Neurotransmitters are integral to the brain's communication system, enabling neurons to transmit signals across synapses. This chemical exchange underpins various cognitive functions, including memory processes. The role of neurotransmitters in memory is multifaceted, influencing the encoding, consolidation, and retrieval of memories through their action on different neural circuits.
 Glutamate and Synaptic Plasticity
Glutamate, the brain's main excitatory neurotransmitter, is...
2.4K
Long-term Potentiation01:35

Long-term Potentiation

58.2K
Long-term potentiation, or LTP, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTP is the process of synaptic strengthening that occurs over time between pre- and postsynaptic neuronal connections. The synaptic strengthening of LTP works in opposition to the synaptic weakening of long-term depression (LTD) and together are the main mechanisms that underlie learning and memory.
58.2K
Long-term Potentiation01:25

Long-term Potentiation

3.4K
Long-term potentiation, or LTP, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTP is the process of synaptic strengthening that occurs over time between pre and postsynaptic neuronal connections. The synaptic strengthening of LTP works in opposition to the synaptic weakening of long-term depression (LTD) and together are the main mechanisms that underlie learning and memory.
Hebbian LTP
LTP can occur when...
3.4K
Cognitive Enhancers: Cholinesterase Inhibitors and NMDA Receptor Antagonists01:30

Cognitive Enhancers: Cholinesterase Inhibitors and NMDA Receptor Antagonists

523
Cognitive enhancers, also known as "smart drugs," are substances used to enhance memory, mental alertness, and concentration. These can be natural or synthetic and improve cognition in conditions like Alzheimer's disease (AD) and other neurodegenerative diseases. Some common examples include caffeine, amphetamines, methylphenidate, modafinil, arecoline, donepezil, vortioxetine, and piracetam. These enhancers work on the principle of synaptic plasticity and altered circuit function.
523
Long-term Depression01:03

Long-term Depression

3.0K
Long-term depression, or LTD, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTD is the process of synaptic weakening that occurs over time between pre and postsynaptic neuronal connections. The synaptic weakening of LTD works in opposition to synaptic strengthening by long-term potentiation (LTP) and together are the main mechanisms that underlie learning and memory.
Calcium Ion Concentration Mechanism
If over...
3.0K
Long-term Depression01:05

Long-term Depression

33.0K
Long-term depression, or LTD, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTD is the process of synaptic weakening that occurs over time between pre and postsynaptic neuronal connections. The synaptic weakening of LTD works in opposition to synaptic strengthening by long-term potentiation (LTP) and together are the main mechanisms that underlie learning and memory.
33.0K

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

Hippocampal ERK2 dimerization regulates inhibitory avoidance memory reconsolidation and synaptic plasticity.

iScience·2026
Same author

Passive Physiological Responses Fail to Predict Context-Dependent Action Selection in Bats.

bioRxiv : the preprint server for biology·2026
Same author

Ultrastructural changes at auditory nerve synapses following moderate noise exposure.

bioRxiv : the preprint server for biology·2026
Same author

Dinner Date: Opposite-Sex Pairs of Fruit Bats (<i>Rousettus aegyptiacus</i>) Forage More than Same-Sex Pairs.

Biology·2025
Same author

BattyCoda: A novel open-source software for bat call annotation and classification.

Ecological informatics·2025
Same author

Strategies for relapse prevention among people with schizophrenia in KwaZulu-Natal Province, South Africa: Healthcare providers' perspectives.

PloS one·2025
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关实验视频

Updated: Jan 10, 2026

Purification of H3 and H4 Histone Proteins and the Quantification of Acetylated Histone Marks in Cells and Brain Tissue
09:43

Purification of H3 and H4 Histone Proteins and the Quantification of Acetylated Histone Marks in Cells and Brain Tissue

Published on: November 30, 2018

22.1K

抑制HDAC6驱动突触蛋白乙化,并增强老鼠的长期记忆力.

Sebastián Rivas1,2, Laura Esquivel1, Julia Busso1

  • 1Laboratory of Synaptic Plasticity and Memory, Faculty of Exact and Natural Sciences, University of Buenos Aires/National Council for Scientific and Technical Research (UBA-CONICET), C1428, Autonomous City of Buenos Aires, Argentina.

Molecular neurobiology
|November 21, 2025
PubMed
概括

基因组脱乙酶6 (HDAC6) 抑制通过增加海马体中的氨酸乙化来增强记忆巩固. 这表明非歇斯顿蛋白的乙化对记忆形成至关重要.

关键词:
乙化 乙化是一种整合 整合 整合在海马体内,海马体长期记忆 长期记忆 长期记忆突触突触是一个突触突触.

更多相关视频

Improved Preparation and Preservation of Hippocampal Mouse Slices for a Very Stable and Reproducible Recording of Long-term Potentiation
09:39

Improved Preparation and Preservation of Hippocampal Mouse Slices for a Very Stable and Reproducible Recording of Long-term Potentiation

Published on: June 26, 2013

27.6K
Preparation of Acute Hippocampal Slices from Rats and Transgenic Mice for the Study of Synaptic Alterations during Aging and Amyloid Pathology
14:57

Preparation of Acute Hippocampal Slices from Rats and Transgenic Mice for the Study of Synaptic Alterations during Aging and Amyloid Pathology

Published on: March 23, 2011

95.1K

相关实验视频

Last Updated: Jan 10, 2026

Purification of H3 and H4 Histone Proteins and the Quantification of Acetylated Histone Marks in Cells and Brain Tissue
09:43

Purification of H3 and H4 Histone Proteins and the Quantification of Acetylated Histone Marks in Cells and Brain Tissue

Published on: November 30, 2018

22.1K
Improved Preparation and Preservation of Hippocampal Mouse Slices for a Very Stable and Reproducible Recording of Long-term Potentiation
09:39

Improved Preparation and Preservation of Hippocampal Mouse Slices for a Very Stable and Reproducible Recording of Long-term Potentiation

Published on: June 26, 2013

27.6K
Preparation of Acute Hippocampal Slices from Rats and Transgenic Mice for the Study of Synaptic Alterations during Aging and Amyloid Pathology
14:57

Preparation of Acute Hippocampal Slices from Rats and Transgenic Mice for the Study of Synaptic Alterations during Aging and Amyloid Pathology

Published on: March 23, 2011

95.1K

科学领域:

  • 神经科学是一个神经科学.
  • 分子生物学分子生物学
  • 生物化学 生物化学

背景情况:

  • 希斯脱乙酶抑制剂影响记忆巩固.
  • 合成蛋白的乙化对塑性至关重要,包括长期增强 (LTP).

研究的目的:

  • 调查非希斯蛋白乙化在长期抑制性回避 (IA) 记忆巩固中的作用.
  • 在这个过程中探索基因组脱乙酶6 (HDAC6) 的特定参与.

主要方法:

  • 使用HDAC6抑制剂Tubastatin A,获得后记忆.
  • 在体外和体内对素乙化水平的评估.
  • 在海马体样本中分析突触蛋白组成和乙化.
  • 在初级海马神经元培养物中化学LTP诱导.

主要成果:

  • 图巴斯A增强了IA记忆巩固,当获得后立即给予,但不超过3小时后.
  • 图巴斯丁A在体外和体内维护和增加了氨酸乙化.
  • 在IA任务训练中,在特定的突触残留物中改变了管氨酸乙化.
  • 化学LTP增加了树突和突触乙化和PSD95集群密度.

结论:

  • 在记忆巩固过程中,HDAC6在调节图林乙化中发挥着重要作用.
  • 非歇斯顿蛋白的乙化,特别是涉及突素,对于记忆形成很重要.
  • 这些发现为基础记忆巩固的分子机制提供了新的见解.