改变宿主和肠道微生物群的干预措施对肉症或其定义参数的影响:基于营养的干预研究的系统审查和元分析
Laurence Lapauw1, Nadjia Amini2, Emiel Switsers3
1Department of Public Health and Primary Care, division of Gerontology and Geriatrics, KU Leuven, Leuven, Belgium. laurence.lapauw@kuleuven.be.
Aging clinical and experimental research
|November 21, 2025
概括
特定的饮食和益生菌可以改善老年人的肌肉力量和步行速度. 高蛋白饮食可能会增强女性的肌肉质量,特别是在更长的干预期间.
科学领域:
- 老年学是一门学科.
- 营养科学 营养科学
- 微生物组研究 微生物组研究
背景情况:
- 骨肌肉质量和功能逐渐丧失的萨科佩尼亚严重影响老年人的健康和独立性.
- 肠道微生物群 (GM) 变化越来越多地被认为是肉症的潜在调节者.
- 改变宿主和转基因的干预措施为石病管理提供了一个有希望的途径.
研究的目的:
- 系统地审查和综合饮食和肠道微生物群调节干预措施对肉类症参数的影响.
- 评估益生菌,益生菌,共生菌和各种饮食策略对老年人群肌肉力量,质量和步行速度的影响.
主要方法:
- 在六个数据库和一个注册表中进行了对50岁及以上人口的干预措施的全面搜索.
- 随机效应模型被用于定量数据的元分析,用I2>50%来评估异质性.
- 进行了偏差风险和GRADE评估,以评估证据的质量和确定性.
主要成果:
- 益生菌干预显著改善了肌肉力量 (1.90公斤) 和步行速度 (0.08米/秒).
- 富含纤维的饮食增强了肌肉力量 (1.25公斤),而能量限制的饮食在60岁以下的个体和12周内改善了肌肉质量.
- 高蛋白饮食对女性的肌肉质量产生了积极的影响,并且当干预持续至少12周时.
结论:
- 富含纤维的饮食和益生菌在改善肌肉力量方面表现出有效性.
- 益生菌对步行速度也有好处,而高蛋白饮食可以在特定条件下增强肌肉质量.
- 未来的研究应该纳入便分析,以阐明肠道微生物群在调解这些与肉类相关的影响中的作用.
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