新生儿高氧暴露不会加剧由母亲肥胖症编程的高血压
Jussara M do Carmo1, John E Hall1, Xuemei Dai1
1Department of Physiology and Biophysics, Mississippi Center for Obesity Research, Cardiorenal and Metabolic Diseases Research Center, University of Mississippi Medical Center, Jackson, Mississippi, United States.
概括
新生儿高氧症 (HO) 在瘦或肥胖母亲的后代中没有增加血压. 相反,HO暴露意外降低了肥胖母亲后代的血压和减弱心脏功能障碍.
科学领域:
- 生理学 生理学 生理学
- 发展生物学 发展生物学
- 新生儿护理 新生儿护理
背景情况:
- 孕产妇肥胖与早产和子女高血压风险增加有关.
- 新生儿接触氧气,特别是氧气治疗,在早产婴儿中很常见,特别是那些出生于肥胖母亲的婴儿.
- 新生儿高氧症对后代血压调节的影响,特别是在母亲肥胖的背景下,尚未完全理解.
研究的目的:
- 调查新生儿高氧 (HO) 是否会导致瘦母亲后代血压升高.
- 为了确定HO是否会加剧母亲肥胖对后代的不良影响.
- 评估HO对瘦身和肥胖母亲后代心脏功能的影响.
主要方法:
- 来自瘦身和高脂肪饮食诱导的肥胖母亲的男性和女性斯普拉格-道利后代从出生后3-10天被暴露在室内空气或80%的氧气 (HO) 中.
- 在12周大时,后代接受了远程测量,以测量血压和心率 (HR).
- 心脏功能,包括+dP/dt_max,评估了来自瘦身和肥胖母亲的后代.
主要成果:
- 与假设相反,新生儿HO与精瘦母亲的后代的血压降低有关,与对照组相比.
- 在肥胖母亲的高血压后代中,HO还降低了BP和HR.
- 新生儿HO与精瘦后代的心脏收缩率降低 (+dP/dt_max) 相关,但在肥胖后代心脏功能障碍减弱.
结论:
- 新生儿高氧暴露似乎与成年早期血压升高无关.
- HO不会加剧母亲肥胖对后代高血压的影响.
- 新生儿高氧症可能在减轻肥胖母亲后代早期心脏功能障碍方面发挥保护作用.
相关概念视频
01:29Hypertension II: Pathophysiology
698
Hypertension is a chronic condition in which the blood's force against artery walls is excessively high, posing risks such as heart disease. The condition's underlying mechanisms involve complex interactions among the cardiovascular, kidney, and autonomic nervous systems.Renin-Angiotensin-Aldosterone System (RAAS): This system significantly influences blood pressure regulation. When blood pressure decreases, the kidneys secrete renin. This enzyme transforms angiotensinogen, a plasma protein,...
698
01:18Hypertension and Regulation of Blood Pressure
3.6K
Hypertension, the most common cardiovascular disease, is diagnosed through repeated measurements of elevated blood pressure. Its risks, including damage to the kidney, heart, and brain, are directly proportional to blood pressure levels. Starting from 115/75 mm Hg, the risk of cardiovascular disease doubles with each increment of 20/10 mm Hg. The diagnosis relies on blood pressure measurements, not on patient symptoms, as hypertension is often asymptomatic until end-organ damage is imminent or...
3.6K
01:33Hormonal Regulation
35.6K
The renin-aldosterone system is an endocrine system which guides the renal absorption of water and electrolytes, thus managing blood pressure and osmoregulation. Activation of the system begins in the kidneys with a small cluster of cells adjacent to the afferent and efferent blood vessels of the renal corpuscle. As the nephrons are filtering blood, juxtaglomerular cells monitor blood pressure. If they detect a decrease in pressure, they release the hormone renin into the bloodstream.
35.6K
01:28Hypertension I: Introduction
653
Hypertension is a widespread, long-term medical condition where blood pressure in the arteries remains elevated. It is characterized by systolic blood pressure readings of 130 mm Hg or above or diastolic blood pressure (DBP) readings of 80 mm Hg or higher. Unmanaged hypertension poses significant health risks, making the distinction between primary (or essential) hypertension and secondary hypertension crucial, as their management and implications vary.Primary HypertensionPrimary hypertension,...
653
01:20Pharmacokinetics in Obese Patients: Drug Metabolism and Excretion
149
Drug metabolism, a critical process in the liver, involves two primary phases: Phase I reactions and Phase II conjugation. Obesity introduces significant alterations in this metabolic process, primarily due to fatty infiltration of the liver, leading to conditions such as nonalcoholic fatty liver disease (NAFLD). This condition can modify the activities of both Phase I and II enzymes, impacting how drugs are metabolized in obese patients.Phase I metabolism sees variable effects across...
149
01:23Hypertension V: Nursing Management
328
The nursing management of hypertension involves accurately assessing symptoms, making a comprehensive nursing diagnosis, collaborating with patients to set goals, and implementing targeted interventions to mitigate the condition's impact and improve patient well-being.Comprehensive AssessmentThe initial step in nursing care for hypertension involves a thorough patient assessment. It includes evaluating symptoms such as headaches, dizziness, blurred vision, and previous hypertension episodes.
328