用碳酸无水酶抑制剂对尿路结石形成的不成比例分析:VigiBase分析
Jonathan J Song1, James McAndrew Jones2, David S Wang2
1Boston University Chobanian and Avedisian School of Medicine, Boston, Massachusetts.
Urology practice
|November 21, 2025
概括
碳酸酶抑制剂 (CAI) 与尿路结石的风险更高有关,特别是在年轻的患者和那些为而服用它们的人群中. 高剂量增加这种风险,需要患者咨询.
科学领域:
- 药物监督 药物监督 药物监督
- 腎臟病學 (nephrology) 是一種醫學專業.
- 药品安全 药品安全
背景情况:
- 碳酸酶抑制剂 (CAI) 的使用正在增加,但它们与尿路结石形成的关联尚未得到充分研究.
- 尿路结石代表了可能与CAI使用相关的显著不良药物反应 (ADR).
研究的目的:
- 研究碳酸酶抑制剂 (CAI) 与与石头相关的不良药物反应 (ADR) 之间的关联.
- 探索剂量依赖关系,并确定特定的患者亚组,这些患者有较高的CAI相关尿路结石风险.
主要方法:
- 使用VigiBase进行了一项药监案例与非案例研究,VigiBase是关于不良事件报告的全球数据库.
- 不成比例分析,包括报告几率比率 (ROR) 和95%置信区间 (CI),用于评估CAI和石质形成之间的关联.
主要成果:
- CAI显示与石头相关的副作用有显著的关联 (ROR 5.02).
- 托皮拉胺,尼沙胺和乙胺与增加结石形成风险特别相关.
- 较年轻的患者 (<45岁) 和那些使用CAI治疗症状的患者表现出更高的风险,对托皮拉和佐尼萨米德观察到剂量依赖的关联.
结论:
- 碳酸酶抑制剂与与石头相关的ADRs的剂量依赖报告有显著的相关性.
- 年轻患者和有症状的患者的风险增加.
- 对于服用CAI的患者,建议就尿路结石发展风险进行临床咨询.
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