中年和老年中华人的估计脉冲波速度和中风之间的关联:全国性的队列研究
Xiaomei Zheng1,2, Yixian Zhang1, Pengsheng Chen3
1Department of Rehabilitation medicine, Fujian Medical University Union Hospital, Fuzhou, China.
PloS one
|November 21, 2025
概括
较高的估计脉冲波速度 (ePWV) 表明中国老年人中风风险增加. 这一发现支持使用ePWV进行早期中风风险查和个性化预防策略.
科学领域:
- 心血管流行病学心血管流行病学
- 血管健康 血管健康
- 公共卫生 公共卫生
背景情况:
- 关于估计的脉冲波速度 (ePWV) 和中风风险之间的联系,研究有限.
- 这项研究通过检查中国成年人的关联来解决这一差距.
研究的目的:
- 调查ePWV与中风风险之间的关系.
- 在中年和老年人群中识别潜在的中风早期查标志物.
主要方法:
- 这是一项对9,190名中国健康与退休长度研究 (CHARLS) 参与者的队列研究.
- ePWV值被分为分层.
- 考克斯比例危险回归模型被用于分析纵向关联与中风风险.
主要成果:
- 与第一个三角形相比,ePWV的第二个和第三个三角形都显示出与中风风险增加的显著关联.
- 第二个三位数的风险增加了40% (HR=1.40),第三个三位数的风险增加了42% (HR=1.42).
- 观察到ePWV和中风风险之间的非线性剂量反应关系.
结论:
- 升高的ePWV与中年和老年中国人的中风风险更高有显著联系.
- ePWV可以作为早期中风风险查的宝贵工具.
- 这些发现可以指导针对中风的个性化预防和干预策略.
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