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癌症中长非编码RNA的功能,药物基因组和免疫景观

Runhao Wang^1,2,3, Mei Luo^1,2,3, Yuan Liu^1,2,3

¹Department of Biostatistics and Health Data Science, Indiana University School of Medicine, Indianapolis, IN, 46202, USA.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)

|November 21, 2025

概括

长非编码RNAs (lncRNAs) 在癌症中至关重要. 这项研究揭示了它们与向疗法,免疫疗法和患者结果的联系,提供了新的诊断和治疗途径.

科学领域:

在瘤学瘤学.
基因组学就是基因组学.
生物信息学是一种生物信息学.

背景情况:

长非编码RNAs (lncRNAs) 越来越多地被认为是它们在癌症发育和进展中的调节作用.
它们作为生物标志物和治疗点的潜力需要对各种癌症类型进行全面分析.

研究的目的:

系统地调查 lncRNAs 与向疗法,免疫疗法和大量癌症患者的临床结果之间的关联.
确定特定的 lncRNAs,可以预测对癌症治疗的反应,并影响与免疫相关的不良事件 (irAEs).

主要方法:

利用癌症基因组图谱 (TCGA) 和现实世界的数据集来全面分析lncRNA表达.
综合了CancerRxTissue和VAEN的数据,以确定lncRNA与药物反应的关联.
与免疫检查点,透,免疫治疗反应和irAEs相关联的lncRNA表达.

主要成果:

确定了超过53,000个lncRNA路径关联和数百万个lncRNA药物反应关联.
发现了69个与免疫疗法反应相关的lncRNA和2611个与客观响应率 (ORR) 相比差异表达的lncRNA.
发现了两个与irAE相关的lncRNA,并确定了1376个lncRNA,在低和高的irAE风险组之间存在差异.

结论:

lncRNAs在调节对癌症治疗,包括向和免疫疗法的反应方面发挥着重要作用.
已识别的 lncRNAs 作为预测治疗疗效和管理irAEs的潜在生物标志物.
开发的网络门户网站PILNC为探索癌症中的lncRNA功能提供了宝贵的资源,并促进了进一步的研究.

关键词:

在 LncRNAs 中.癌症信号通路是癌症的信号通路.药物反应药物反应免疫检查点的检查点.免疫透免疫透是什么?免疫疗法的有效性免疫疗法的有效性美国的IRAAEAE

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