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Updated: Jun 24, 2026

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在微塑料暴露下视觉评估糖尿病模型的Dipeptidyl Peptidase IV激活近红外光探针

Xiao Sun1,2, Yan Huang1, Lili Fu3,4

  • 1School of Pharmacy, Binzhou Medical University, Yantai 264003, China.

Analytical chemistry
|November 21, 2025
PubMed
概括

微塑料 (MPs) 可能对2型糖尿病患者 (T2DM) 造成伤害. 一个新的光探测器Cy-DPP在暴露于MP的T2DM模型中检测到增加的DPP4水平,有助于诊断和MP毒性研究.

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相关概念视频

Dipeptidyl Peptidase 4 Inhibitors01:23

Dipeptidyl Peptidase 4 Inhibitors

Dipeptidyl peptidase 4 (DPP-4) is a serine protease widely distributed in the body. It's involved in the inactivation of GLP-1 and GIP hormones, which are crucial for insulin regulation. DPP-4 inhibitors, such as sitagliptin (Januvia), saxagliptin (Onglyza), linagliptin (Tradjenta), alogliptin (Nesina), and vildagliptin (Galvus), help increase the proportion of active GLP-1, enhancing insulin secretion. These inhibitors work by competitively binding to DPP-4. This binding causes a significant...