心脏代谢健康和体力强度映射出大脑结构和神经递质系统的不同模式
Eliana Nicolaisen-Sobesky1,2, Somayeh Maleki Balajoo1,2, Mostafa Mahdipour1,2
1Institute of Neuroscience and Medicine (INM-7: Brain and Behaviour), Research Centre Jülich, Jülich, Germany.
PLoS biology
|November 21, 2025
概括
心脏代谢健康和体力强度显著影响大脑结构,影响皮质厚度和灰质体积. 这些因素与神经递质系统和炎症有关,强调了对大脑健康的整体方法.
科学领域:
- 神经科学是一个神经科学.
- 公共卫生 公共卫生
- 医疗成像医学成像
背景情况:
- 非传染性疾病的风险因素与大脑健康有关,但具体影响尚不清楚.
- 了解这些联系对于开发精确的大脑健康策略至关重要.
- 现有的研究往往忽略了生活方式因素和大脑结构之间的多变量关系.
研究的目的:
- 研究非传染性疾病风险因素与大脑结构 (皮层厚度和灰质体积) 之间的多变量关系.
- 从系统层面的角度来描述这些关系,包括大脑形态,功能和神经递质系统.
- 探索风险因子尺寸和外周炎症标志物之间的关联.
主要方法:
- 利用了来自英国生物库的数据 (n=7,370,年龄46-81岁).
- 在机器学习框架内使用规范化正规相关性分析 (RCCA) 来识别隐藏的维度.
- 通过旋转测试将已识别的大脑模式与结构,功能和神经递质系统数据相关联;通过斯皮尔曼相关性检查了与C反应蛋白 (CRP) 的炎症关联.
主要成果:
- 确定了两个重要的潜在维度:一个是将心脏代谢健康与不同性别的大脑结构 (皮质厚度/灰质体积) 联系起来,另一个是将身体强度与大脑结构联系起来,对皮质厚度有性别特异的影响.
- 两个维度都显示了与神经递质系统的关联.
- 心脏代谢健康维度与CRP相关,而体力强度显示出较弱的关联.
结论:
- 在心脏代谢健康,体力强度和大脑结构 (皮层厚度,灰质体积,神经递质系统) 之间建立了强大的多层次联系.
- 观察到与这些因素相关的大脑结构的增加和减少,表明复杂的关系.
- 研究结果支持整体健康视角,整合神经认知和身体健康,并挑战疾病的分类概念化,慢性炎症的潜在作用.
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