一个体体的accumbens路径通过一个厌恶的Esr1+下丘脑-大脑管回路驱动刻板的行为
Thomas Contesse1, Buse Yel Bektash1, Marta Graziano1
1Department of Neuroscience, Karolinska Institutet, Stockholm, Sweden.
Science advances
|November 21, 2025
概括
研究人员在大脑中发现了一条特定的神经通路,它驱动着强迫行为. 激活这种途径会取代自然奖励和社会互动,突出显示它在动机行为中的作用.
科学领域:
- 神经科学是一个神经科学.
- 行为神经科学 行为神经科学
- 分子精神病学分子精神病学
背景情况:
- 侧下垂体区域 (LHA) 对于整合内部状态和外部刺激来引导有动机的行为至关重要.
- 了解激发行为和强迫行为背后的神经回路对于解决相关疾病至关重要.
研究的目的:
- 为了识别和表征一个特定的神经元亚型在核 (ACB) 和其投射到LHA.
- 研究ACB-LHA-侧面大脑 (LHb) 途径在调节动机和强迫行为中的作用.
主要方法:
- 利用光遗传学进行细胞类型特定和输入输出定义的神经通路的激活.
- 雇佣行为测试来评估有动机和强迫性的行为.
- 研究了行为状态对特定神经群体 (例如Esr1+ LHA神经元) 的依赖性.
主要成果:
- 在ACB中定义了一个状体Tac1+/Tshz1+/Oprm1+神经元亚型,准Esr1+ LHA神经元向LHb投射.
- 对ACB-LHA-LHb通路的光遗传激活诱导了依赖于Esr1+ LHA-LHb神经活动的负面行为状态.
- 激活D1+ACB-LHA投射或抑制ACB输入定义的LHA-LHb神经元驱动了奖励独立的强迫性行为,这些行为在各种环境中概括.
结论:
- 一个离散的 Tac1+ 体体 ACB 投射针对的是厌恶性的 Esr1+ LHA-LHb 途径.
- 这种电路促进了刻板印象和强迫性行为,而不是目标导向的行为,甚至超越了自然奖励和社会驱动.
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