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新兴PFOA替代品的下一代风险评估,使用综合新方法方法

You Song¹, Xueqi Fan², Maria T Hultman¹

¹Norwegian Institute for Water Research (NIVA), Økernveien 94, N-0579 Oslo, Norway.

Environmental science & technology

|November 21, 2025

概括

新兴的per-和多醇基物质 (PFAS) 替代品带来当地环境风险,其中一些显示细胞毒性和胚胎毒性. 在下一代风险评估 (NGRA) 框架内的新方法方法 (NAM) 有效评估了这些风险.

科学领域:

环境化学环境化学
毒理学毒理学毒理学
风险评估风险评估

背景情况:

全球对像 perfluorooctanoic acid (PFOA) 这样的遗留per-和polyfluoroalkyl物质 (PFAS) 的限制,刺激了替代化学品的开发和环境存在的增加.
评估这些新兴的PFAS替代品对环境的影响对于保护生态系统和人类健康至关重要.

研究的目的:

评估和比较与八种PFOA替代品相关的当地环境风险.
展示下一代风险评估 (NGRA) 框架使用新方法方法 (NAMs) 的实用性.

主要方法:

应用NGRA框架,整合废水和地表水的有针对性的化学分析.
使用in silico建模,体外斑马鱼肝细胞测试,体内斑马鱼胚胎毒性测试和转录基因分析进行危险性表征.
导出多个起点 (PODs),包括基准度 (BMC) 和转录性POD (tPOD),并计算风险系数 (RQ).

主要成果:

HFPO-TA和HFPO-TeA表现出细胞毒性;HFPO-DA,HFPO-TA和HFPO-TeA引起了显著的胚胎毒性.
HFPO-TeA被确定为最强大的替代品,转录组数据表明代谢和心血管功能受到干扰.
对于HFPO-DA的风险系数超过了关注值,而对HFPO-TA和HFPO-TeA的调整后的风险系数表明关注程度降低了.

结论:

新兴的PFOA替代品可能会带来重大的当地环境风险,需要仔细评估.
基于NAM的NGRA框架为评估替代化学品风险提供了一个强大而有效的方法.
调查结果强调了积极评估化学替代品的环境风险的重要性.

关键词:

在 AOP AOP 中.这个名字是NAM NAM.恩格拉 (NGRA) 是一个在PFAS中,我们可以使用PFAS.这是SSD,SSD是SSD.tPODD可以使用.证据的权重是证据的权重.斑马鱼是一种斑马鱼.

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