在周周期间的异质皮质醇模式:从纵向轨迹分析的见解
Jelena Dukic1, Alexandra Johann1, Mirka Henninger2
1Clinical Psychology and Psychotherapy, University of Zurich, Zurich, Switzerland.
Psychoneuroendocrinology
|November 21, 2025
概括
在怀孕期间和分娩后出现了两种不同的母体皮质醇模式. 大多数女性显示稳定,较低的水平,而一个子组持续升高,可变的皮质醇,表明不同的HPA轴调节.
科学领域:
- 内分泌学 在内分泌学.
- 神经科学是一个神经科学.
- 生殖健康 生殖健康
背景情况:
- 母体下丘脑-垂体-上腺 (HPA) 轴在怀孕和产后期间显示出显著的变化.
- 皮质醇分泌模式表现出相当多的异质性和矛盾的结果在周边研究.
- 个人皮质醇分泌模式及其决定因素尚未得到充分理解.
研究的目的:
- 在产前期识别出不同的母体皮质醇分泌模式.
- 探索皮质醇轨迹与社会人口统计学/心理因素之间的关联.
- 了解怀孕和产后期间HPA轴调节的异质性.
主要方法:
- 在127名健康孕妇的长度队列研究中.
- 唾液皮质醇测量在五个时间点,从怀孕晚期到产后8周.
- 基于小组的轨迹建模用于识别不同的皮质醇分泌模式.
主要成果:
- 确定了两个不同的皮质醇轨迹组:大多数 (79-86%) 具有稳定,较低的水平,一个子组 (14-21%) 具有持续升高的,可变的水平.
- 高分类稳定性 (98-99%) 对于轨迹组.
- 在社会人口统计学或心理变量与群体成员身份之间没有发现显著的关联.
结论:
- 在产前期存在两种不同的母性皮质醇轨迹,表明HPA轴调节的异质性.
- 未测量的因素,可能是遗传或表观遗传,可能会影响这些皮质醇模式.
- 不同的皮质醇轨迹可以解释之前的周周皮质醇研究中的不一致性,并突出不同的神经内分泌调节模式.
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