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在肺腺癌中通过空气空间传播 (STAS):形态模式,密度和程度的预后影响

Sinem Eser Polat Ünal¹, Canan Sadullahoğlu¹, Hacer Boztepe Yeşilçay²

¹Department of Pathology, Health Sciences University, Antalya Hospital, Varlik, Kazim Karabekir Street, 07100, Muratpasa, Antalya, Turkey.

Annals of diagnostic pathology

|November 21, 2025

概括

肺腺癌中通过空气空间传播 (STAS) 与较差的生存率有关. 分析STAS的存在,亚型,密度和程度揭示了肺癌患者风险分层的显著预后价值.

科学领域:

肺部病理学肺部病理学
在瘤学瘤学.
手术病理学手术病理学

背景情况:

通过空气空间传播 (STAS) 是肺腺癌的新兴入侵模式.
STAS形态特征的预后意义需要进一步定义.

研究的目的:

分析肺腺癌中STAS的存在,形态亚型,密度和程度.
评估STAS特征与临床病理参数和患者存活率之间的关系.

主要方法:

组织病理学检查184个手术切除的肺腺癌.
评估STAS的存在,亚型 (固体,微毛囊群,单细胞扩散),扩展和密度.
与临床病理学参数和生存结果 (总生存率和无复发生存率) 的相关性分析.

主要成果:

在67.9%的瘤中检测到STAS,固体是最常见的亚型.
STAS阳性与瘤模式,等级,膜入侵,淋巴血管入侵 (LVI),复发,转移,PN阶段,OS和DFS有显著的相关性.
高密度的STAS和广泛的STAS与较差的OS和DFS显著相关.

结论:

STAS及其特定特征 (亚型,密度,程度) 在肺腺癌中具有显著的预后价值.
这些发现强调了评估STAS对改善患者风险分层的临床相关性.
对STAS的进一步研究可以完善肺腺癌患者的治疗策略和预后.

关键词:

肺部腺癌瘤是肺部腺癌.预后预后预测预测斯塔斯·斯塔斯 (STAS) 是一个通过空气空间传播.

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