PanGeneWhale - 一个基于Kotlin的GUI平台,用于可复制和用户友好的泛基因组分析
Walter de Barros Gomes Netto1, Saed Silva Sousa2, Sofia Mayumi Brandao Nakamaru3
1Biological Engineering Laboratory, Guamá Science and Technology Park, Belém, Pará, Brazil.
Computational biology and chemistry
|November 21, 2025
概括
通过将多种工具集成到一个用户友好的平台,PanGeneWhale简化了泛基因组分析. 这种计算工具提高了研究微生物基因组的研究人员的可访问性和可重复性.
科学领域:
- 基因组学就是基因组学.
- 生物信息学是一种生物信息学.
- 计算生物学 计算生物学
背景情况:
- 泛基因组分析工具在可用性,性能和复杂性方面面临挑战.
- 这些障碍限制了可访问性和可重复性,需要先进的计算专业知识.
研究的目的:
- 开发PanGeneWhale,一个统一的计算平台,简化泛基因组分析.
- 提高大规模基因组研究的可访问性,可复制性和效率.
主要方法:
- 在Docker容器环境中集成多个泛基因组分析工具.
- 开发一个直观的,跨平台的图形用户界面.
- 使用50个大肠杆菌基因组进行验证,并对计算性能进行基准测试.
主要成果:
- PanGeneWhale成功地集成了各种工具,自动化了执行流程,并确保了可重复的结果.
- 基准测试揭示了工具之间的性能差异,这是PanGeneWhale解决的问题.
- 识别并解决了关键的可用性问题,如过时的依赖关系和缺乏GUI.
结论:
- PanGeneWhale显著提高了所有技能水平的研究人员对泛基因组分析的可访问性和效率.
- 该平台提高了大规模基因组研究的实用性和可靠性.
- PanGeneWhale克服了以前的局限性,使先进的泛基因组分析更容易管理.
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