优化复杂尾炎的抗生素治疗:对短期和长期疗程的系统审查
Joe C Elhage1, Ahmed Hussein Abdelbaset2, Marafi Jammaa Ahmed3
1Faculty of Medicine, American University of Beirut, Beirut, Lebanon.
The Journal of surgical research
|November 21, 2025
概括
短期抗生素 (≤5天) 与较长时间的抗生素对复杂的尾炎一样有效和安全. 这种方法显著减少了住院时间,并支持了抗生素管理.
科学领域:
- 传染性疾病 传染性疾病
- 外科手术的结果
- 药物治疗 药物治疗
背景情况:
- 复杂的尾炎经常需要术后抗生素,但最佳持续时间仍在争论中.
- 长时间使用抗生素可能会在尾炎治疗中带来风险,但没有明显的益处.
研究的目的:
- 评估短期 (≤5天) 与较长时间的术后抗生素治疗复杂尾炎的疗效和安全性.
- 为了比较关键的临床结果,包括感染率,死亡率和住院时间.
主要方法:
- 在主要数据库 (PubMed,Embase,Scopus,Web of Science,Cochrane Library) 进行了系统的文献搜索,截至2025年4月.
- 包括随机对照试验和队列研究,比较短期与长期抗生素持续时间的尾切除术后.
- 分析使用了DerSimonian和Laird随机效应模型来评估结果.
主要成果:
- 分析了13项涉及5325名患者的研究.
- 在短期和长期抗生素组之间,没有观察到腹腔内,手术部位感染,死亡率或再入院率的显著差异.
- 短期抗生素组的住院时间显著缩短 (平均差异=-1.907天).
结论:
- 短期的术后抗生素治疗对于管理复杂的尾炎来说是非劣质和安全的.
- 实施短期治疗方案可以减少住院时间,并可能减轻与抗生素相关的并发症.
- 标准化短期抗生素治疗方案可以改善患者的治疗结果,并促进有效的抗生素管理.
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