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n-Butylphthalide通过直接与Keap1结合来缓解由肥胖引起的心肌病

Yixiao Yan1, Cheng Xiang1, Xuelian Wang1

  • 1Oujiang Laboratory (Zhejiang Lab for Regenerative Medicine, Vision and Brain Health), School of Pharmaceutical Science, Wenzhou Medical University, Wenzhou, Zhejiang 325000, PR China.

International immunopharmacology
|November 21, 2025
PubMed
概括

通过准Keap1/Nrf2通路,n-Butylphthalide (NBP) 通过准Keap1/Nrf2通路来治疗肥胖引起的心脏损伤. 这种抗氧化剂阻止Keap1抑制Nrf2,减少氧化应激,改善心脏功能.

关键词:
抗氧化剂是一种抗氧化剂.凯尔奇类的ECH相关蛋白-1 (Keap1)甲 (NBP) 是一种甲 (N-butylphthalide) 的化合物.核因子红色素2相关因子2 (Nrf2) 的核因子.肥胖心肌病症 肥胖心肌病症

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