在巴西治疗与代谢功能障碍相关的脂肪肝炎的resmetirom的成本效益
Windson Hebert Araújo Soares1, Guilherme Grossi Lopes Cançado2, André Soares Motta-Santos3
1Health Management and Care Analyst, Hospital Foundation of the State of Minas Gerais, Belo Horizonte, Brazil.
Value in health regional issues
|November 21, 2025
概括
雷斯米蒂罗姆在治疗与代谢功能障碍相关的脂肪肝炎方面更有效,但在巴西并不具有成本效益. 需要进一步分析覆盖范围的决定.
科学领域:
- 药物经济学 药物经济学
- 肝病学 肝病学是一种肝病学.
- 卫生技术评估 卫生技术评估
背景情况:
- 代谢功能障碍相关的脂肪肝炎 (MASH) 是一个日益严重的健康问题.
- 需要有效和经济有效的MASH治疗方法.
- 雷斯米蒂罗姆是MASH的潜在治疗剂.
研究的目的:
- 评估resmetirom在巴西MASH治疗中的成本效益.
- 将resmetirom的成本和结果与巴西医疗保健系统内的安慰剂进行比较.
主要方法:
- 使用了20年的马尔科夫模型,模拟了7种健康状况,从缺乏纤维化到死亡率.
- 成本以巴西雷亚尔 (BRL) 和PPP-USD来衡量,结果以质量调整的寿命年 (QALY) 来衡量.
- 进行了敏感性分析,以评估研究结果的可靠性.
主要成果:
- 与安慰剂相比,Resmetirom显示了121,762PPP-USD的增量成本和1.05QALY的收益.
- 增量成本效益比 (ICER) 大约为40 017PPP-USD/QALY.
- 该模型表明resmetirom在巴西的标准支付意愿门上没有成本效益.
结论:
- 对于MASH,resmetirom比安慰剂更有效,但成本更高.
- 该药在巴西的成本效益低于传统的值.
- 建议对有关resmetirom.irom的保险和退款决定保持谨慎.
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