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Updated: Jan 10, 2026

Fluorescence-microscopy Screening and Next-generation Sequencing: Useful Tools for the Identification of Genes Involved in Organelle Integrity
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Published on: April 13, 2012

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一个基于显微镜的CRISPR选平台使有机细胞功能基因组学成为可能,并阐明了状生物学的知识

Jingbo Sun1, Irem Sude Atiş1, Stéfany L L Empke2

  • 1Department of Molecular, Cellular, and Developmental Biology, Yale University, New Haven, CT, USA.

Developmental cell
|November 21, 2025
PubMed
概括

我们开发了一个新的CRISPR查平台,使用光显微镜对细胞成像进行基因分析. 这种方法识别了初级乳毛结构和功能的调节者,揭示了新的基因功能.

关键词:
这是一个CRISPR屏幕.一个人的心态 axonemeeme.西里亚西里亚是什么意思纤毛病是一种纤毛病.功能性基因组学 功能性基因组学这是一种微型蛋白质.通过光学选进行选.聚氨基化聚氨基化.过渡区的过渡区.

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Genetic screens are tools used to identify genes and mutations responsible for phenotypes of interest. Genetic screens help identify individuals or a group of people at risk of developing  genetic diseases and help them with early intervention, targeted therapy, and reproductive options.
Forward genetic screens
Forward or “classical” genetic screens involve creating random mutations in an organism’s DNA using radiation, mutagens, or insertion of additional bases, which...
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Bacteria and archaea are susceptible to viral infections just like eukaryotes; therefore, they have developed a unique adaptive immune system to protect themselves. Clustered regularly interspaced short palindromic repeats and CRISPR-associated proteins (CRISPR-Cas) are present in more than 45% of known bacteria and 90% of known archaea.
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