在美洲原住民中增加了与他类药物相关的免疫媒介性死性肌肉病的流行率和发病率

Tam N Dinh¹, Evelyn E Inga¹, Yvonne M Waters²

¹Department of Internal Medicine, University of New Mexico Health Sciences Center, MSC 10 5550, 5th FL ACC, Albuquerque, NM, 87131, USA.

Rheumatology (Oxford, England)

|November 21, 2025

概括

与他类药物相关的免疫媒介性死肌病 (IMNM) 在美国西南部的美洲原住民中明显更为普遍. 虽然美国原住民和非美国原住民的治疗方法和结果相似,但需要进一步研究遗传和环境因素.

科学领域:

类风湿病学类风湿病学
免疫学免疫学免疫学
遗传学是一个遗传学.

背景情况:

类他类药物相关的免疫媒介性死肌病 (IMNM) 是一种严重的异常性炎症性肌病 (IIM),与抗-3-基-3-甲基氨酸共酶A减酶 (抗HMGCR) 抗体有关.
了解IIM和IMNM的人口变化对于有针对性的医疗保健和研究至关重要.

研究的目的:

为了比较美洲原住民 (NA) 与非美洲原住民 (非NA) 在美国西南部被诊断患有IIM和他类药物相关的IMNM的特征和结果.
确定这些人群中与他类药物相关的IMNM的流行率和发病率.

主要方法:

对148名IIM患者 (33名NA,115名非NA) 的回顾性单一机构研究.
基于标准标准的IIM诊断;与他类药物相关的IMNM需要抗HMGCR抗体.
在NA和非NA组之间对人口,临床,实验室参数和结果进行比较.

主要成果:

与非NA相比,患有IIM的美国土著人表现出更高的超脂血症,他类药物暴露,糖尿病和食道不运动率.
美国原住民更频繁地检测出抗RNP和抗HMGCR抗体呈阳性.
据估计,与他类药物相关的IMNM的患病率和发病率在美洲原住民中明显高 (分别为182vs30.6例/10^6人口和66.4vs7.5例/年/10^6人口).

结论:

与他类药物相关的IMNM在美国西南地区的美洲原住民中明显更为常见.
对于与他类药物相关的IMNM的临床结果和治疗反应在美洲原住民和非美洲原住民之间似乎是相似的.
进一步调查导致印第安人IMNM易感性的遗传和环境因素是必不可少的.

关键词:

在HMGCR中,HMGCR是最重要的.本土的土著居民.自动抗体是一种自身抗体.创造因激酶酶的作用是什么这是土著的土著.骨髓病变是一种神经病变.肌肉性肌肉性炎症肌肉性肌肉炎死性死症的人.斯塔丁是一个国家.

相关概念视频

01:20

Myasthenia Gravis: Overview and Treatment

2.7K

Myasthenia gravis is a neuromuscular transmission disorder characterized by weakness and increased fatigability of skeletal muscles. It is an autoimmune disease affecting approximately one in 2000 people, where antibodies against the α1 subunit of nicotinic acetylcholine receptors are produced.
These antibodies interfere with the function of the nicotinic receptors in three ways: by binding to the receptor and disrupting acetylcholine binding; by causing cross-linking of receptors which...

2.7K

01:20

Lipid-Lowering Drugs: Statins and Miscellaneous Agents

1.3K

Hyperlipidemia, a medical condition often referred to as high cholesterol, is characterized by abnormally elevated levels of lipids in the bloodstream. When present in excess, these lipids, specifically cholesterol and triglycerides, can lead to serious health complications, often involving cardiovascular diseases. Illnesses like atherosclerosis, heart attacks, and pancreatitis have all been linked to untreated hyperlipidemia. This means controlling and regulating cholesterol and triglyceride...

1.3K

01:21

Myocarditis I: Introduction

347

Myocarditis is inflammation of the myocardium, which is the muscular layer of the heart.EtiologyMyocarditis has a diverse etiology, including a wide range of infectious and non-infectious causes:Infectious CausesViral: Common viruses include Coxsackie A and B, adenovirus, parvovirus B19, enteroviruses, and influenza A.Bacterial: Examples include infections caused by Streptococcus, Staphylococcus, and Mycoplasma species.Rickettsial: Infections like Rocky Mountain spotted fever can result in...

347

01:27

Myocarditis II: Clinical Features and Diagnostic Tests

242

Myocarditis is an inflammation of the heart muscle. The symptoms vary widely, encompassing asymptomatic presentations to severe, acute manifestations.Clinical PresentationAsymptomatic cases: In some instances, myocarditis may be asymptomatic, with the infection resolving without intervention. These cases often go undetected unless discovered incidentally through diagnostic imaging or tests conducted for other reasons.General Early Symptoms: Early symptoms of myocarditis are non-specific and can...

242

01:14

Myocarditis III: Medical Management

165

Myocarditis: Comprehensive Medical ManagementMyocarditis, the heart muscle inflammation, requires a comprehensive medical management strategy that addresses the underlying cause, provides supportive care, manages symptoms, and reduces cardiac workload.Infections and Autoimmune CausesAdminister appropriate antimicrobial therapy when an infectious agent causes myocarditis. For instance, penicillin treats infections caused by Group A Streptococcus. In cases where autoimmune processes are...

165

01:22

Myocarditis IV: Nursing Management

197

Myocarditis is an inflammatory condition of the myocardium requiring meticulous nursing management for optimal patient outcomes. Effective management begins with a thorough assessment of the patient's medical history, paying close attention to past infections, autoimmune disorders, travel history, and exposure to toxins or drugs. Recent viral infections and systemic diseases are particularly relevant due to their potential role in triggering myocarditis.Physical Examination and MonitoringThe...

197