基于芝麻油和pectin水凝的乳化剂的开发和表征,用于营养药物输送
Dheerendra Kumar Suman1, Kunal Pal2, Manasa P3
1Department of Biotechnology, National Institute of Technology, Andhra Pradesh, Tadepalligudem, Andhra Pradesh, 534101, India.
International journal of biological macromolecules
|November 21, 2025
概括
使用芝麻油和pectin的新乳化系统可提供控制的营养药物. 这些配方显示出有希望的pH依赖释放和增强的肠道透,表明改善治疗应用的潜力.
科学领域:
- 制药科学 制药科学
- 材料科学 材料科学 材料科学
- 生物技术是生物技术.
背景情况:
- 营养药需要有效的输送系统以获得最佳的生物可用性.
- 乳化剂为封装脂友化合物提供了一个多功能平台.
- 芝麻油和点是天然成分,有可能用于药物输送.
研究的目的:
- 开发和描述基于乳的营养药物输送系统,使用芝麻油和点.
- 评估开发的乳化剂的物理化学性质,药物释放动力学和ex vivo透性.
- 评估这些乳膜的安全性和潜力,以控制营养药物输送.
主要方法:
- 用不同度的芝麻油和点氨酸制备乳化剂.
- 使用显微镜,FTIR,XRD和机械测试进行表征.
- 在不同pH值的体外释放研究和使用山羊肠的体外透研究.
- 通过MTT测定进行细胞毒性评估.
主要成果:
- 乳化物表现出双相性质和无形结构.
- 机械坚固度随着芝麻油含量增加而增加.
- 观察到pH值依赖的黄素释放,配方之间存在显著差异.
- 活体研究表明,对于优化的配方,肠道透率提高.
- 配方对人类上皮细胞无细胞毒性.
结论:
- 基于芝麻油和pectin的乳化剂系统适用于受控的营养药物输送.
- 配方成分显著影响释放特征和透.
- 这些乳化剂显示出增强生物可用性和治疗疗效的潜力.
- 开发的系统可以安全地用于人类上皮细胞.
相关概念视频
01:17Pore Transport and Ion-Pair Transport
Pore transport and ion-pair formation are critical mechanisms for the absorption and distribution of drugs in the body.
Pore transport, also known as convective transport, is a process where small molecules like urea, water, and sugars rapidly cross cell membranes as though there were channels or pores in the membrane. Although direct microscopic evidence is limited but the concept of pores or channels is widely accepted based on physiological evidence. Despite the lack of direct microscopic...
Pore transport, also known as convective transport, is a process where small molecules like urea, water, and sugars rapidly cross cell membranes as though there were channels or pores in the membrane. Although direct microscopic evidence is limited but the concept of pores or channels is widely accepted based on physiological evidence. Despite the lack of direct microscopic...
01:24Site-Targeted Drug Delivery Systems: Polymeric Carriers
Polymeric carriers enhance targeted drug delivery by increasing efficacy while minimizing off-target effects. These carriers comprise a biodegradable polymeric backbone integrated with functional elements that enable targeting, improve physicochemical properties, and regulate drug release.Targeting MechanismsThe targeting ability of polymeric carriers is mediated by a homing device, which is a molecular recognition component designed to selectively bind to specific tissues or cells. Monoclonal...