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Updated: Jan 10, 2026

A Cancer Cell Spheroid Assay to Assess Invasion in a 3D Setting
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球体间的近距离和矩阵重塑决定了与癌症相关的纤维细胞介导癌细胞入侵

Pranav Mehta1, Ankur Deep Bordoloi2, Cor Ravensbergen3

  • 1Department of Cell and Chemical Biology and Oncode Institute, Leiden University Medical Center, Leiden, the Netherlands; Department of Chemical Engineering, Delft University of Technology, Van der Maasweg 9, 2629 HZ, Delft, the Netherlands.

Acta biomaterialia
|November 21, 2025
PubMed
概括

与癌症相关的纤维细胞 (CAFs) 在乳腺癌细胞入侵之前重塑细胞外基质 (ECM). 向CAF可能通过破坏CAF驱动的ECM重塑和细胞扩散来提供治疗效益.

关键词:
乳腺癌是什么? 乳腺癌是什么癌细胞的入侵 癌细胞的入侵与癌症相关的纤维细胞 (CAFs).原蛋白是一种原蛋白.细胞外矩阵 (ECM) 是一个细胞外矩阵.不同质的球形形状.矩阵改造 矩阵改造

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