解读阿尔茨海默病中的血脑屏障功能障碍:多式核磁共振和PET成像生物标志物的创新和挑战
Haolin Yin1, Zihao Lu1, Yuepeng Deng1
1Department of Radiology, Huaxi MR Research Center (HMRRC), Institute of Radiology and Medical Imaging，Psychoradiology Key Laboratory of Sichuan Province, West China Hospital of Sichuan University, Chengdu, Sichuan, China; Research Unit of Psychoradiology, Chinese Academy of Medical Sciences, Chengdu, Sichuan, China; Xiamen Key Lab of Psychoradiology and Neuromodulation, Department of Radiology, West China Xiamen Hospital of Sichuan University, Xiamen, Fujian, China.
Ageing research reviews
|November 21, 2025
概括
这篇评论强调了先进的MRI和PET成像如何揭示阿尔茨海默病 (AD) 中血脑屏障 (BBB) 功能障碍. 这些技术对于理解AD的发病因子和开发新的诊断和治疗策略至关重要.
科学领域:
- 神经成像是一种神经成像.
- 神经退行性疾病 神经退行性疾病
- 血管生物学 血管生物学
背景情况:
- 血脑屏障 (BBB) 功能障碍是阿尔茨海默病 (AD) 发病的一个关键因素.
- BBB调节了粉样β (Aβ) 和蛋白的清除,这在AD中至关重要.
- BBB的分解会加剧Aβ的积累和神经炎症.
研究的目的:
- 审查当前的体内MRI和PET成像技术,以评估AD中的BBB分解.
- 综合BBB功能障碍的可视化进展及其在AD中的作用.
- 探索新兴的策略,以改善AD中的BBB成像.
主要方法:
- 动态对比增强MRI测量BBB泄漏的数量.
- 水交换MRI评估跨BBB的水动态.
- 使用像[18F]-氧葡萄糖和[11C]-维拉帕米尔这样的标记物进行PET成像,以评估新陈代谢和传送器功能.
主要成果:
- 核磁共振和PET技术可以可视化BBB功能障碍,包括微妙的泄漏和改变的运输.
- 图像检测揭示了BBB赤字,Aβ清除受损和AD早期代谢变化之间的联系.
- 目前的方法在灵敏度,量化和分辨率方面面临挑战.
结论:
- 先进的MRI和PET成像是了解BBB在AD中的作用的重要工具.
- 多式成像,人工智能和新型的追踪器对未来的AD诊断和治疗有希望.
- 建议转向超越粉样蛋白的多目标干预措施的范式转变.
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