空气污染与青少年灰质发育之间的纵向关联:来自ABCD研究的见解
Calvin A Jara1, Scott A Jones2, Bonnie J Nagel3
1School of Medicine, Oregon Health & Science University, Portland, OR, USA.
Environmental research
|November 21, 2025
概括
空气污染,包括细颗粒物 (PM2.5) 和二氧化 (NO2),与青少年大脑皮层更快地变薄有关. 这种神经发育影响可能会影响认知和情绪健康.
科学领域:
- 神经科学是一个神经科学.
- 环境健康 环境健康
- 公共卫生 公共卫生
背景情况:
- 空气污染是一个全球性的健康问题,影响身体和神经健康.
- 青少年特别容易受到空气污染的影响,因为他们的大脑正在持续发育.
- 有限的纵向研究存在于空气污染对青少年大脑结构的影响.
研究的目的:
- 研究PM2.5,NO2和O3暴露与青少年皮层厚度之间的纵向关联.
- 检查空气污染物如何改变青春期神经发育轨迹.
主要方法:
- 利用了青少年大脑认知发展 (ABCD) 研究的10,947名参与者的数据.
- 将地理编码的住宅地址与监管空气监测数据联系起来,以估计暴露.
- 采用线性混合效应模型来分析污染物暴露和皮质厚度之间的关联,这些关联来自于在2-3波中收集的结构性MRI数据.
主要成果:
- 增加对PM2.5和NO2的暴露与前额和部区域的加速皮质稀释有关.
- 这些大脑区域对于执行功能和社会情绪处理至关重要.
- 臭氧 (O3) 与皮质形态学的相关性很小.
结论:
- 空气污染,特别是PM2.5和NO2,可能会通过加速皮层稀释,对青少年的神经发育产生负面影响.
- 这些发现表明对认知和情绪结果的潜在长期影响.
- 减少空气污染对于支持健康的青少年大脑发育至关重要.
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