酸盐,双和儿童过敏现象:来自两个出生队列研究的结果
Thomas Boissiere-O'Neill1, Nina Lazarevic2, Anne-Louise Ponsonby3
1The University of Queensland, Child Health Research Centre, The Children's Health and Environment Program QLD, 4101, Australia.
早期暴露于甲酸盐可能会增加儿童非型喘的风险. 这项研究发现了甲酸盐暴露和亚托皮性与非亚托皮性喘表型之间的差异性关联.
科学领域:
- 环境健康 环境健康
- 儿科过敏 儿科过敏
- 毒理学 毒理学 毒理学
背景情况:
- 儿童过敏性疾病是一个越来越令人担忧的问题.
- 酸盐和双是常见的环境化学物质.
- 它们对喘和非喘的差异性影响尚不清楚.
研究的目的:
- 调查早期暴露在酸盐和双醇中是否对亚托皮性和非亚托皮性喘有不同的影响.
- 为了检查产前和产后暴露窗口.
主要方法:
- 利用两个出生队列 (澳大利亚和加拿大) 提供详细的暴露数据.
- 在怀孕和幼儿时期评估尿甲和双代谢物.
- 在4-5岁时被诊断出喘,喘息,湿疹和鼻炎,通过皮肤刺痛测试评估了亚托皮.
- 采用量子式G计算和贝叶斯内核机器回归,通过阿托皮分层.
主要成果:
- 产前甲酸盐混合物与非阿托皮性喘有很强的关联,有证据表明,阿托皮性喘改变了效果.
- 产后的甲酸盐混合物也与非阿托皮性喘有关.
- 甲酸盐混合物显示出不同的关联模式 (U形,反向U形,线性) 对于无性与非无性喘.
- 产前双A显示与整体喘息的反向关联.
结论:
- 早期的甲酸盐暴露似乎对儿童喘风险产生了差异性的影响.
- 研究结果表明,酸盐可能在非阿托皮性喘的发展中发挥更重要的作用.
- 需要进一步的研究来阐明具体的机制和化学影响.
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