重新评估男性不孕不育的未知原因:阿米比亚सिस作为一个新兴的病因
Alaa A Noor1, Hazar S Saleh2, Fadhil A Al-Abady2
1Biology Department, College of Education for Pure Sciences, University of Thi -Qar, Iraq; Ministry of Education, Directorate of Thi-Qar Education, Mutafawqat School, Al-Shatrah, Iraq.
Parasitology international
|November 21, 2025
概括
在雄性大鼠中,Entamoeba histolytica感染导致了完全的生育失败. 这种寄生虫对生殖组织造成严重损伤,损害了精子生产和激素水平.
科学领域:
- 生殖生物学 生殖生物学
- 传染性疾病 传染性疾病
- 毒理学 毒理学 毒理学
背景情况:
- 不孕症是一个重要的多因素医疗挑战,特别是当原因不明时.
- Entamoeba histolytica因其侵入性而闻名,目前正在研究其在男性不孕症中的潜在作用.
研究的目的:
- 调查Entamoeba histolytica感染与男性不孕症之间的潜在关联.
- 评估E. histolytica对雄性大鼠生殖组织,精子参数和激素水平的影响.
主要方法:
- 雄性大鼠感染了E. histolytica,并进行了生育能力评估.
- 使用PCR和组织学分析了丸和上皮组织.
- 评估了精子数量,运动性和形态学.
- 测量了,FSH,LH,益生菌素和雌激素的血清水平.
主要成果:
- 在受感染的老鼠的丸和 epididymal 组织中检测到 E. histolytica DNA.
- 组织病理学揭示了精卵管退化和精子生成细胞枯竭.
- 观察到精子数量和运动率的显著减少,异常增加.
- 荷尔蒙失衡包括和FSH的降低,以及益生素和雌激素的增加.
- 受感染的老鼠显示出0%的怀孕率,表明完全的生育能力失败.
结论:
- Entamoeba histolytica感染与大鼠的雄性生殖功能受损有关.
- 病理性,精子生成性和内分泌变化表明存在因果关系.
- 需要进一步的研究来确认人类的临床相关性.
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