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Insensitive Nuclei Enhanced by Polarization Transfer (INEPT)

Insensitive Nuclei Enhanced by Polarization Transfer (INEPT)

Insensitive Nuclei Enhanced by Polarization Transfer (INEPT) is an advanced Nuclear Magnetic Resonance (NMR) technique specifically designed to detect and enhance the signals of low-abundance nuclei, such as carbon-13 and nitrogen-15, in small molecules. The fundamental principle behind INEPT is the transfer of polarization from a more abundant and highly polarizable nucleus, typically hydrogen-1, to the low-abundance nucleus of interest. This process effectively boosts the NMR signal of the...

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Updated: Jan 10, 2026

Quantification of Protein Interaction Network Dynamics using Multiplexed Co-Immunoprecipitation

Quantification of Protein Interaction Network Dynamics using Multiplexed Co-Immunoprecipitation

Published on: August 21, 2019

看到光 (链):在PGNMID的一个范式转变.

Jean Hou¹, Mark Haas¹

¹Department of Pathology and Laboratory Medicine, Cedars-Sinai Medical Center, Los Angeles, California, USA.

Kidney international

|November 21, 2025

概括

大多数具有单克隆Ig沉积的增殖性淋巴结膜炎病例缺乏真正的单克隆性,这挑战了它们的分类和治疗. 新证据表明,这些脏疾病可能不是来自单个异常的血细胞克隆.

科学领域:

腎臟病學 (nephrology) 是一種醫學專業.
免疫学免疫学免疫学
病理学病理学病理学

背景情况:

具有单克隆Ig沉积 (PGMID) 的增殖性淋巴结膜炎在历史上是由单个免疫球蛋白 (Ig) 同型的淋巴结膜沉积定义的.
这些Ig沉积物的单克隆性受到质疑,因为难以检测单克隆性副蛋白.

研究的目的:

重新评估免疫球蛋白沉积在具有单克隆Ig沉积的增殖性血球炎中的单克隆性.
评估沉积单克隆性对PGIMD被归类为关键单克隆性胃病变 (MGRS) 的影响.

主要方法:

利用高度敏感和特定的方法来分析脏活检中的免疫球蛋白沉积物.
研究了质体内免疫球蛋白蛋白的存在和克隆性.

主要成果:

在大多数具有单克隆Ig沉积病例的增殖性血球炎病例中,提供了强有力的证据反对真正的单克隆性.
证明这些脏疾病中的免疫球蛋白沉积通常是多克隆的或表现出模糊的克隆性.

结论:

这些发现挑战了目前对具有单克隆Ig沉积的增殖性球炎的定义和分类.
结果表明,PGIMD可能并不总是代表具有性意义的单克隆性胃病变,可能会改变治疗策略.

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A Fast and Quantitative Method for Post-translational Modification and Variant Enabled Mapping of Peptides to Genomes

A Fast and Quantitative Method for Post-translational Modification and Variant Enabled Mapping of Peptides to Genomes

Published on: May 22, 2018

Optimization of Synthetic Proteins: Identification of Interpositional Dependencies Indicating Structurally and/or Functionally Linked Residues

Optimization of Synthetic Proteins: Identification of Interpositional Dependencies Indicating Structurally and/or Functionally Linked Residues

Published on: July 14, 2015

相关实验视频

Last Updated: Jan 10, 2026

Quantification of Protein Interaction Network Dynamics using Multiplexed Co-Immunoprecipitation

Quantification of Protein Interaction Network Dynamics using Multiplexed Co-Immunoprecipitation

Published on: August 21, 2019

A Fast and Quantitative Method for Post-translational Modification and Variant Enabled Mapping of Peptides to Genomes

A Fast and Quantitative Method for Post-translational Modification and Variant Enabled Mapping of Peptides to Genomes

Published on: May 22, 2018

Optimization of Synthetic Proteins: Identification of Interpositional Dependencies Indicating Structurally and/or Functionally Linked Residues

Optimization of Synthetic Proteins: Identification of Interpositional Dependencies Indicating Structurally and/or Functionally Linked Residues

Published on: July 14, 2015