在大鼠体内内源性形成并口服的低分子量高级糖化最终产品的组织分布
Xiyu Li1, Yaxin Sang2, Xiaohan Liu2
1College of Food Science and Technology, Hebei Agricultural University, Baoding 071000, China; Division of Toxicology, Wageningen University, PO Box 8000, 6700, EA, Wageningen, the Netherlands.
Food research international (Ottawa, Ont.)
|November 21, 2025
概括
外源性高级糖化终产物 (AGEs) 是生物可用的,并积聚在老鼠脏中,具有明显的组织分布模式. 口服有助于AGE的整体暴露,特别是在脏中.
科学领域:
- 生物化学 生物化学
- 毒理学 毒理学 毒理学
- 药理动力学 药理动力学
背景情况:
- 先进的糖化终产物 (AGEs) 涉及到各种病理.
- 了解AGE的吸收,分布,新陈代谢和分泌 (ADME) 对于评估其对健康的影响至关重要.
- 由于其潜在的生物可用性,低分子量 (LMM) AGEs特别感兴趣.
研究的目的:
- 在大鼠中量化口服四种LMM AGEs的组织分布.
- 为了比较外源地注射的AGE与内源地形成的AGE的分布.
- 调查口服AGE摄入对整体暴露组的贡献.
主要方法:
- 在小鼠体内分泌4种LMM AGEs (GALA,CEL,CML,Pyrraline) 的混合物,每种为10mg/kg体重.
- 在各种老鼠组织中量化自由的外源和内源AGE,在给药后两小时.
- 分析组织特异性分布模式,并比较外源和内源AGE水平.
主要成果:
- 外源性地注射的AGE在小鼠组织中可检测到两小时后.
- 脏显示出外源AGE的最高度,明显高于内源水平.
- 对于四种AGE,观察到不同的组织特异分布模式,表明吸收,分布和/或清除的差异.
结论:
- 在口服后,自由AGE具有生物可用性.
- 不同的LMM AGEs之间存在不同的组织生物分布和消除模式.
- 口服暴露于AGE,特别是在脏中,在估计的每日摄入水平下,有助于AGE的整体暴露.
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