开发一个核心的结果集的 sciatica:一个范围审查的结果措施的措施
Katie Ridsdale1, Jonathan Woodward2, Ifsah Asad3
1Sheffield Centre for Health and Related Research, The University of Sheffield, Sheffield, UK k.ridsdale@sheffield.ac.uk.
BMJ open
|November 21, 2025
概括
坐骨髓炎研究缺乏标准化的结果指标,阻碍了数据分析. 这项对187项试验的审查发现了69项患者报告结果措施 (PROM),突出了对持续的 sciatica 研究的核心结果集的需求.
科学领域:
- 临床研究 临床研究
- 疼痛管理 疼痛管理
- 健康 结果 研究 研究 结果
背景情况:
- 结果测量的标准化对于合成坐骨髓炎研究至关重要.
- 患者报告的结果测量 (PROMs) 对于评估 sciatica 干预措施至关重要.
- 当前的 sciatica 研究在结果测量中表现出异质性.
研究的目的:
- 识别和分类用于 sciatica 的随机对照试验中的 PROM.
- 为开发基于共识的核心成果集提供基础,用于坐骨神经炎研究.
- 分析PROM使用模式,收集时间点和干预类型.
主要方法:
- 进行了范围审查.
- 在MEDLINE,Embase和Cochrane中央数据库 (1999-2024) 中进行系统搜索.
- 包括涉及 sciatica 患者的随机对照试验,使用至少一个 PROM,独立查和数据提取.
主要成果:
- 187项研究使用了69种不同的PROM,其中视觉模拟疼痛量表,奥斯韦斯特残疾指数和数值疼痛评分量表是最常见的.
- PROM主要针对病理生理学和生命影响领域,仅限于经济影响.
- 在研究中观察到随访期和PROM施用方法的显著差异.
结论:
- 在 sciatica 试验中,结果测量的实质性异质性存在,这强调了标准化的需要.
- 频繁使用非脊髓灰质炎特异性的测量方法可能表明,在捕捉特定病情的结果方面存在差距.
- 制定标准化的核心成果集对于提高 sciatica 研究的质量和可比性至关重要.
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