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Updated: Jul 25, 2026

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在小鼠中,TAAR1缺乏会损害线粒体动力学和中部前额叶皮质的突触完整性,以及相关的认知能力

Xian-Qiang Zhang1, Jing Xiong1, De-Nong Liu1

  • 1Peking University Sixth Hospital, Peking University Institute of Mental Health, NHC Key Laboratory of Mental Health (Peking University), National Clinical Research Center for Mental Disorders (Peking University Sixth Hospital), Beijing, 100191, China.

Translational psychiatry
|November 21, 2025
PubMed
概括

在中部前额叶皮层的微氨基相关受体1 (TAAR1) 缺乏会损害线粒体和突触功能,导致小鼠的认知缺陷. 这突显了TAAR1在维持大脑健康方面的作用,并提供了对神经精神疾病的见解.

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相关概念视频

Tail-anchoring of Proteins in the ER Membrane01:45

Tail-anchoring of Proteins in the ER Membrane

Tail-anchored, or TA, proteins are estimated to make up to 3-5% of membrane proteins found in the eukaryotic cell. Such proteins have a single transmembrane domain located approximately 30 amino acid residues upstream from the C-terminal end. As a result, the signal recognition particle (SRP) cannot guide a TA protein to the ER membrane for cotranslational insertion. Hence, they are integrated into the ER membrane post-translationally using their C-terminal end as the anchor. TA proteins...